Why does viral RNA sometimes persist after recovery from acute infections?
DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after cl...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-06-01
|
| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3001687 |
| _version_ | 1811295075254140928 |
|---|---|
| author | Diane E Griffin |
| author_facet | Diane E Griffin |
| author_sort | Diane E Griffin |
| collection | DOAJ |
| description | DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms, such as may be the case following infection with Ebola or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does viral RNA sometimes persist after recovery from an acute infection? Where does the RNA come from? And what are the consequences? |
| first_indexed | 2024-04-13T05:26:55Z |
| format | Article |
| id | doaj.art-c28b972dcf7340bc9dcbdebbed964a1a |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-13T05:26:55Z |
| publishDate | 2022-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-c28b972dcf7340bc9dcbdebbed964a1a2022-12-22T03:00:34ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852022-06-01206e300168710.1371/journal.pbio.3001687Why does viral RNA sometimes persist after recovery from acute infections?Diane E GriffinDNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms, such as may be the case following infection with Ebola or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does viral RNA sometimes persist after recovery from an acute infection? Where does the RNA come from? And what are the consequences?https://doi.org/10.1371/journal.pbio.3001687 |
| spellingShingle | Diane E Griffin Why does viral RNA sometimes persist after recovery from acute infections? PLoS Biology |
| title | Why does viral RNA sometimes persist after recovery from acute infections? |
| title_full | Why does viral RNA sometimes persist after recovery from acute infections? |
| title_fullStr | Why does viral RNA sometimes persist after recovery from acute infections? |
| title_full_unstemmed | Why does viral RNA sometimes persist after recovery from acute infections? |
| title_short | Why does viral RNA sometimes persist after recovery from acute infections? |
| title_sort | why does viral rna sometimes persist after recovery from acute infections |
| url | https://doi.org/10.1371/journal.pbio.3001687 |
| work_keys_str_mv | AT dianeegriffin whydoesviralrnasometimespersistafterrecoveryfromacuteinfections |