Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review
<i>Background/Introduction:</i> Cutaneous mixed tumor is a rare benign neoplasm that exhibits a wide range of metaplastic changes and differentiation in the epithelial, myoepithelial, and stromal components, which is often confused with various other skin lesions. <i>Case report:&l...
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MDPI AG
2023-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/8/1465 |
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| author | Dimitrinka Kisova Tihomir Dikov Vesela Ivanova Hristo Stoyanov Greta Yordanova |
| author_facet | Dimitrinka Kisova Tihomir Dikov Vesela Ivanova Hristo Stoyanov Greta Yordanova |
| author_sort | Dimitrinka Kisova |
| collection | DOAJ |
| description | <i>Background/Introduction:</i> Cutaneous mixed tumor is a rare benign neoplasm that exhibits a wide range of metaplastic changes and differentiation in the epithelial, myoepithelial, and stromal components, which is often confused with various other skin lesions. <i>Case report:</i> We present an unusual case of a 58-year-old woman with a mixed tumor of the upper lip, previously misdiagnosed as adnexal carcinoma on a preoperative biopsy. The excision biopsy shows a well-circumscribed lesion composed of various cells and structures featuring folliculo–sebaceous differentiation embedded in a prominent chondromyxoid stroma. The immunohistochemical study proves the various lineages of differentiation and classifies the neoplasm as the less common eccrine subtype of cutaneous mixed tumor. <i>Discussion:</i> The common embryologic origin of the folliculo–sebaceous apocrine complex leads to a great histological variety of cellular components of mixed tumors and the formation of structures that resemble established types of adnexal neoplasms, which could be a diagnostic pitfall, especially on a small incision biopsy. |
| first_indexed | 2024-03-10T23:45:56Z |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T23:45:56Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-c2903fbd6a18490b9b3537995a6ed16f2023-11-19T02:06:44ZengMDPI AGMedicina1010-660X1648-91442023-08-01598146510.3390/medicina59081465Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature ReviewDimitrinka Kisova0Tihomir Dikov1Vesela Ivanova2Hristo Stoyanov3Greta Yordanova4Department of General and Clinical Pathology, Faculty of Medicine, Medical University Sofia, 1431 Sofia, BulgariaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University Sofia, 1431 Sofia, BulgariaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University Sofia, 1431 Sofia, BulgariaDepartment of Maxillofacial Surgery, Alexandrovska University Hospital, 1431 Sofia, BulgariaDepartment of Orthodontics, Faculty of Dental Medicine, Medical University Sofia, 1431 Sofia, Bulgaria<i>Background/Introduction:</i> Cutaneous mixed tumor is a rare benign neoplasm that exhibits a wide range of metaplastic changes and differentiation in the epithelial, myoepithelial, and stromal components, which is often confused with various other skin lesions. <i>Case report:</i> We present an unusual case of a 58-year-old woman with a mixed tumor of the upper lip, previously misdiagnosed as adnexal carcinoma on a preoperative biopsy. The excision biopsy shows a well-circumscribed lesion composed of various cells and structures featuring folliculo–sebaceous differentiation embedded in a prominent chondromyxoid stroma. The immunohistochemical study proves the various lineages of differentiation and classifies the neoplasm as the less common eccrine subtype of cutaneous mixed tumor. <i>Discussion:</i> The common embryologic origin of the folliculo–sebaceous apocrine complex leads to a great histological variety of cellular components of mixed tumors and the formation of structures that resemble established types of adnexal neoplasms, which could be a diagnostic pitfall, especially on a small incision biopsy.https://www.mdpi.com/1648-9144/59/8/1465skinadnexaltumorseccrine mixed tumorhistopathology |
| spellingShingle | Dimitrinka Kisova Tihomir Dikov Vesela Ivanova Hristo Stoyanov Greta Yordanova Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review Medicina skin adnexal tumors eccrine mixed tumor histopathology |
| title | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
| title_full | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
| title_fullStr | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
| title_full_unstemmed | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
| title_short | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
| title_sort | mixed eccrine cutaneous tumor with folliculo sebaceous differentiation case report and literature review |
| topic | skin adnexal tumors eccrine mixed tumor histopathology |
| url | https://www.mdpi.com/1648-9144/59/8/1465 |
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