Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions
Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues em...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/23/7367 |
| _version_ | 1797400000548831232 |
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| author | Larisa Anghel Bogdan-Sorin Tudurachi Andreea Tudurachi Alexandra Zăvoi Alexandra Clement Alexandros Roungos Laura-Cătălina Benchea Ioana Mădălina Zota Cristina Prisacariu Radu Andy Sascău Cristian Stătescu |
| author_facet | Larisa Anghel Bogdan-Sorin Tudurachi Andreea Tudurachi Alexandra Zăvoi Alexandra Clement Alexandros Roungos Laura-Cătălina Benchea Ioana Mădălina Zota Cristina Prisacariu Radu Andy Sascău Cristian Stătescu |
| author_sort | Larisa Anghel |
| collection | DOAJ |
| description | Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues emerged, due to high incidences of stent thrombosis (ST) linked to death, myocardial infarction, and repeat revascularization. Second-generation DESs were developed to overcome these issues, reducing late-thrombotic-event risk while maintaining anti-restenosis efficacy. Nevertheless, ST still occurs with second-generation DES use. Stent thrombosis etiology is multifaceted, encompassing lesion-, patient-, procedural-, and stent-related factors. Overall, most early-stent-thrombosis cases are linked to procedural and patient-related aspects. Factors like premature discontinuation of dual antiplatelet therapy, resistance to clopidogrel, smoking, diabetes mellitus, malignancy, reduced ejection fraction or undertaking coronary angioplasty for an acute coronary syndrome can increase the risk of stent thrombosis. The aim of this study is to assess patient-related factors that potentially heighten the risk of stent thrombosis, with the objective of pinpointing and addressing modifiable contributors to this risk. By focusing on both patient- and procedure-related factors, a multifaceted approach to coronary revascularization can help minimize complications and maximize long-term benefits in managing ST. |
| first_indexed | 2024-03-09T01:48:16Z |
| format | Article |
| id | doaj.art-c291a9ead1bb43c2a8b505e581830189 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T01:48:16Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c291a9ead1bb43c2a8b505e5818301892023-12-08T15:19:39ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011223736710.3390/jcm12237367Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary InterventionsLarisa Anghel0Bogdan-Sorin Tudurachi1Andreea Tudurachi2Alexandra Zăvoi3Alexandra Clement4Alexandros Roungos5Laura-Cătălina Benchea6Ioana Mădălina Zota7Cristina Prisacariu8Radu Andy Sascău9Cristian Stătescu10Internal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaCardiology Department, Cardiovascular Diseases Institute “Prof. Dr. George I. M. Georgescu”, 700503 Iași, RomaniaCardiology Department, Cardiovascular Diseases Institute “Prof. Dr. George I. M. Georgescu”, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaCardiology Department, Cardiovascular Diseases Institute “Prof. Dr. George I. M. Georgescu”, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaInternal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700503 Iași, RomaniaOver the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues emerged, due to high incidences of stent thrombosis (ST) linked to death, myocardial infarction, and repeat revascularization. Second-generation DESs were developed to overcome these issues, reducing late-thrombotic-event risk while maintaining anti-restenosis efficacy. Nevertheless, ST still occurs with second-generation DES use. Stent thrombosis etiology is multifaceted, encompassing lesion-, patient-, procedural-, and stent-related factors. Overall, most early-stent-thrombosis cases are linked to procedural and patient-related aspects. Factors like premature discontinuation of dual antiplatelet therapy, resistance to clopidogrel, smoking, diabetes mellitus, malignancy, reduced ejection fraction or undertaking coronary angioplasty for an acute coronary syndrome can increase the risk of stent thrombosis. The aim of this study is to assess patient-related factors that potentially heighten the risk of stent thrombosis, with the objective of pinpointing and addressing modifiable contributors to this risk. By focusing on both patient- and procedure-related factors, a multifaceted approach to coronary revascularization can help minimize complications and maximize long-term benefits in managing ST.https://www.mdpi.com/2077-0383/12/23/7367stent thrombosispatient-related factorspercutaneous coronary interventioncardiac deathheart attack |
| spellingShingle | Larisa Anghel Bogdan-Sorin Tudurachi Andreea Tudurachi Alexandra Zăvoi Alexandra Clement Alexandros Roungos Laura-Cătălina Benchea Ioana Mădălina Zota Cristina Prisacariu Radu Andy Sascău Cristian Stătescu Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions Journal of Clinical Medicine stent thrombosis patient-related factors percutaneous coronary intervention cardiac death heart attack |
| title | Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions |
| title_full | Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions |
| title_fullStr | Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions |
| title_full_unstemmed | Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions |
| title_short | Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions |
| title_sort | patient related factors predicting stent thrombosis in percutaneous coronary interventions |
| topic | stent thrombosis patient-related factors percutaneous coronary intervention cardiac death heart attack |
| url | https://www.mdpi.com/2077-0383/12/23/7367 |
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