Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid
Graphene oxide based molecularly imprinted polymer was designed by incorporating vinyltrimethoxysilane into the layers of graphene oxide, which was copolymerized with functional monomers such as Itaconic acid (IA) and methyl methacrylate (MMA) was developed via bulk imprinting technique. The prepare...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Sensors International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666351123000177 |
| _version_ | 1797336915820675072 |
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| author | Gowri Soman Vandana M Gurumurthy Hegde |
| author_facet | Gowri Soman Vandana M Gurumurthy Hegde |
| author_sort | Gowri Soman |
| collection | DOAJ |
| description | Graphene oxide based molecularly imprinted polymer was designed by incorporating vinyltrimethoxysilane into the layers of graphene oxide, which was copolymerized with functional monomers such as Itaconic acid (IA) and methyl methacrylate (MMA) was developed via bulk imprinting technique. The prepared polymer was studied for selective sensing the uric acid (UA) in blood serum. The electrode was constructed by modifying bare glassy carbon electrodes with the prepared molecularly imprinted polymer (MIP) via drop cast method. Electrochemical measurements were made by Cyclic voltammetric (CV) and Differential Pulse Voltammetric (DPV) response of the sensor. The physical and chemical properties of the resultant material will be characterized by FTIR spectroscopy, XRD and FESEM. The constructed sensor showed a regression coefficient (R2) of 0.9302 with limit of detection (LOD) of about 0.565 μM. The developed sensor is reusable without any compromise in its selectivity. All the results confirm that the constructed biosensor requires no pre-treatment of samples and is suitable for real sample analysis. |
| first_indexed | 2024-03-08T09:00:50Z |
| format | Article |
| id | doaj.art-c298105f0c834793a8404e8c84b8b4e1 |
| institution | Directory Open Access Journal |
| issn | 2666-3511 |
| language | English |
| last_indexed | 2024-03-08T09:00:50Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sensors International |
| spelling | doaj.art-c298105f0c834793a8404e8c84b8b4e12024-02-01T06:35:21ZengKeAi Communications Co., Ltd.Sensors International2666-35112023-01-014100243Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acidGowri Soman0Vandana M1Gurumurthy Hegde2Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, IndiaDepartment of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, IndiaDepartment of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Bangalore, 560029, India; Corresponding author. Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India.Graphene oxide based molecularly imprinted polymer was designed by incorporating vinyltrimethoxysilane into the layers of graphene oxide, which was copolymerized with functional monomers such as Itaconic acid (IA) and methyl methacrylate (MMA) was developed via bulk imprinting technique. The prepared polymer was studied for selective sensing the uric acid (UA) in blood serum. The electrode was constructed by modifying bare glassy carbon electrodes with the prepared molecularly imprinted polymer (MIP) via drop cast method. Electrochemical measurements were made by Cyclic voltammetric (CV) and Differential Pulse Voltammetric (DPV) response of the sensor. The physical and chemical properties of the resultant material will be characterized by FTIR spectroscopy, XRD and FESEM. The constructed sensor showed a regression coefficient (R2) of 0.9302 with limit of detection (LOD) of about 0.565 μM. The developed sensor is reusable without any compromise in its selectivity. All the results confirm that the constructed biosensor requires no pre-treatment of samples and is suitable for real sample analysis.http://www.sciencedirect.com/science/article/pii/S2666351123000177Graphene oxideBiosensorElectrochemistryUric acid |
| spellingShingle | Gowri Soman Vandana M Gurumurthy Hegde Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid Sensors International Graphene oxide Biosensor Electrochemistry Uric acid |
| title | Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid |
| title_full | Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid |
| title_fullStr | Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid |
| title_full_unstemmed | Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid |
| title_short | Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid |
| title_sort | molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid |
| topic | Graphene oxide Biosensor Electrochemistry Uric acid |
| url | http://www.sciencedirect.com/science/article/pii/S2666351123000177 |
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