Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an expansive proteostatic network. We have discovered...

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Bibliographic Details
Main Authors: Maria I Lazaro-Pena, Adam B Cornwell, Carlos A Diaz-Balzac, Ritika Das, Zachary C Ward, Nicholas Macoretta, Juilee Thakar, Andrew V Samuelson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
proteostasis
longevity
neuronal cell non-autonomous control
aging
gene expression
homeodomain-interacting protein kinase
Online Access:https://elifesciences.org/articles/85792

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