Gut Immunobiosis and Biomodulators
The human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/9/2114 |
| _version_ | 1797602050434924544 |
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| author | Vito Leonardo Miniello Andrea Miniello Laura Ficele Aleksandra Skublewska-D’Elia Vanessa Nadia Dargenio Fernanda Cristofori Ruggiero Francavilla |
| author_facet | Vito Leonardo Miniello Andrea Miniello Laura Ficele Aleksandra Skublewska-D’Elia Vanessa Nadia Dargenio Fernanda Cristofori Ruggiero Francavilla |
| author_sort | Vito Leonardo Miniello |
| collection | DOAJ |
| description | The human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immune and metabolic homeostasis of the host, as well as for inhibiting pathogen penetration. In contrast, compositional dysregulation of the microbiota (dysbiosis) is blamed for the determinism of numerous diseases. Although further advances in the so-called ‘omics’ disciplines are needed, dietary manipulation of the gut microbial ecosystem through biomodulators (prebiotics, probiotics, symbionts, and postbiotics) represents an intriguing target to stabilize and/or restore eubiosis. Recently, new approaches have been developed for the production of infant formulas supplemented with prebiotics (human milk oligosaccharides [HMOs], galacto-oligosaccharides [GOS], fructo-oligosaccharides [FOS]), probiotics, and postbiotics to obtain formulas that are nutritionally and biologically equivalent to human milk (closer to the reference). |
| first_indexed | 2024-03-11T04:10:26Z |
| format | Article |
| id | doaj.art-c29bc20f1d3a4cd0acfeb70b47df1280 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:10:26Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c29bc20f1d3a4cd0acfeb70b47df12802023-11-17T23:29:19ZengMDPI AGNutrients2072-66432023-04-01159211410.3390/nu15092114Gut Immunobiosis and BiomodulatorsVito Leonardo Miniello0Andrea Miniello1Laura Ficele2Aleksandra Skublewska-D’Elia3Vanessa Nadia Dargenio4Fernanda Cristofori5Ruggiero Francavilla6Nutrition Unit, Department of Pediatrics, “Giovanni XXIII” Children Hospital, University of Bari Aldo Moro, 70126 Bari, ItalyDepartment of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Policlinico di Bari, 70126 Bari, ItalyNutrition Unit, Department of Pediatrics, “Giovanni XXIII” Children Hospital, University of Bari Aldo Moro, 70126 Bari, ItalyNutrition Unit, Department of Pediatrics, “Giovanni XXIII” Children Hospital, University of Bari Aldo Moro, 70126 Bari, ItalyInterdisciplinary Department of Medicine, Pediatric Section, Children’s Hospital ‘Giovanni XXIII’, University of Bari Aldo Moro, 70126 Bari, ItalyInterdisciplinary Department of Medicine, Pediatric Section, Children’s Hospital ‘Giovanni XXIII’, University of Bari Aldo Moro, 70126 Bari, ItalyInterdisciplinary Department of Medicine, Pediatric Section, Children’s Hospital ‘Giovanni XXIII’, University of Bari Aldo Moro, 70126 Bari, ItalyThe human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immune and metabolic homeostasis of the host, as well as for inhibiting pathogen penetration. In contrast, compositional dysregulation of the microbiota (dysbiosis) is blamed for the determinism of numerous diseases. Although further advances in the so-called ‘omics’ disciplines are needed, dietary manipulation of the gut microbial ecosystem through biomodulators (prebiotics, probiotics, symbionts, and postbiotics) represents an intriguing target to stabilize and/or restore eubiosis. Recently, new approaches have been developed for the production of infant formulas supplemented with prebiotics (human milk oligosaccharides [HMOs], galacto-oligosaccharides [GOS], fructo-oligosaccharides [FOS]), probiotics, and postbiotics to obtain formulas that are nutritionally and biologically equivalent to human milk (closer to the reference).https://www.mdpi.com/2072-6643/15/9/2114gut microbiotaeubiosisdysbiosisbiomodulatorsprebioticsprobiotics |
| spellingShingle | Vito Leonardo Miniello Andrea Miniello Laura Ficele Aleksandra Skublewska-D’Elia Vanessa Nadia Dargenio Fernanda Cristofori Ruggiero Francavilla Gut Immunobiosis and Biomodulators Nutrients gut microbiota eubiosis dysbiosis biomodulators prebiotics probiotics |
| title | Gut Immunobiosis and Biomodulators |
| title_full | Gut Immunobiosis and Biomodulators |
| title_fullStr | Gut Immunobiosis and Biomodulators |
| title_full_unstemmed | Gut Immunobiosis and Biomodulators |
| title_short | Gut Immunobiosis and Biomodulators |
| title_sort | gut immunobiosis and biomodulators |
| topic | gut microbiota eubiosis dysbiosis biomodulators prebiotics probiotics |
| url | https://www.mdpi.com/2072-6643/15/9/2114 |
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