TMS-induced neural noise in sensory cortex interferes with short-term memory storage
In a previous study, Harris et al. (2002) found disruption of vibrotactile short-term memory after applying single-pulse transcranial magnetic stimulation to primary somatosensory cortex (SI) early in the maintenance period, and suggested that this demonstrated a role for SI in vibrotactile memory s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-03-01
|
| Series: | Frontiers in Computational Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncom.2014.00023/full |
| _version_ | 1818981112721965056 |
|---|---|
| author | Tyler D Bancroft Jeremy eHogeveen William E Hockley Philip eServos |
| author_facet | Tyler D Bancroft Jeremy eHogeveen William E Hockley Philip eServos |
| author_sort | Tyler D Bancroft |
| collection | DOAJ |
| description | In a previous study, Harris et al. (2002) found disruption of vibrotactile short-term memory after applying single-pulse transcranial magnetic stimulation to primary somatosensory cortex (SI) early in the maintenance period, and suggested that this demonstrated a role for SI in vibrotactile memory storage. While such a role is compatible with recent suggestions that sensory cortex is the storage substrate for working memory, it stands in contrast to a relatively large body of evidence from human EEG and single-cell recording in primates that instead points to prefrontal cortex as the storage substrate for vibrotactile memory. In the present study, we use computational methods to demonstrate how Harris et al.’s results can be reproduced by TMS-induced activity in sensory cortex and subsequent feedforward interference with memory traces stored in prefrontal cortex, thereby reconciling discordant findings in the tactile memory literature. |
| first_indexed | 2024-12-20T17:26:09Z |
| format | Article |
| id | doaj.art-c29f29a28e8c4f81bbac28ee28f614c6 |
| institution | Directory Open Access Journal |
| issn | 1662-5188 |
| language | English |
| last_indexed | 2024-12-20T17:26:09Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Computational Neuroscience |
| spelling | doaj.art-c29f29a28e8c4f81bbac28ee28f614c62022-12-21T19:31:35ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882014-03-01810.3389/fncom.2014.0002357966TMS-induced neural noise in sensory cortex interferes with short-term memory storageTyler D Bancroft0Jeremy eHogeveen1William E Hockley2Philip eServos3Wilfrid Laurier UniversityWilfrid Laurier UniversityWilfrid Laurier UniversityWilfrid Laurier UniversityIn a previous study, Harris et al. (2002) found disruption of vibrotactile short-term memory after applying single-pulse transcranial magnetic stimulation to primary somatosensory cortex (SI) early in the maintenance period, and suggested that this demonstrated a role for SI in vibrotactile memory storage. While such a role is compatible with recent suggestions that sensory cortex is the storage substrate for working memory, it stands in contrast to a relatively large body of evidence from human EEG and single-cell recording in primates that instead points to prefrontal cortex as the storage substrate for vibrotactile memory. In the present study, we use computational methods to demonstrate how Harris et al.’s results can be reproduced by TMS-induced activity in sensory cortex and subsequent feedforward interference with memory traces stored in prefrontal cortex, thereby reconciling discordant findings in the tactile memory literature.http://journal.frontiersin.org/Journal/10.3389/fncom.2014.00023/fullNoisePrefrontal Cortexcomputational modelingworking memoryshort-term memoryTMS |
| spellingShingle | Tyler D Bancroft Jeremy eHogeveen William E Hockley Philip eServos TMS-induced neural noise in sensory cortex interferes with short-term memory storage Frontiers in Computational Neuroscience Noise Prefrontal Cortex computational modeling working memory short-term memory TMS |
| title | TMS-induced neural noise in sensory cortex interferes with short-term memory storage |
| title_full | TMS-induced neural noise in sensory cortex interferes with short-term memory storage |
| title_fullStr | TMS-induced neural noise in sensory cortex interferes with short-term memory storage |
| title_full_unstemmed | TMS-induced neural noise in sensory cortex interferes with short-term memory storage |
| title_short | TMS-induced neural noise in sensory cortex interferes with short-term memory storage |
| title_sort | tms induced neural noise in sensory cortex interferes with short term memory storage |
| topic | Noise Prefrontal Cortex computational modeling working memory short-term memory TMS |
| url | http://journal.frontiersin.org/Journal/10.3389/fncom.2014.00023/full |
| work_keys_str_mv | AT tylerdbancroft tmsinducedneuralnoiseinsensorycortexinterfereswithshorttermmemorystorage AT jeremyehogeveen tmsinducedneuralnoiseinsensorycortexinterfereswithshorttermmemorystorage AT williamehockley tmsinducedneuralnoiseinsensorycortexinterfereswithshorttermmemorystorage AT philipeservos tmsinducedneuralnoiseinsensorycortexinterfereswithshorttermmemorystorage |