Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma
Many biotic and abiotic stressors impact bees’ health, acting as immunosupressors and contribute to colony losses. Thus, the importance of studying the immune response of honey bees is central to develop new strategies aiming to enhance bees’ fitness to confront the threats affecting them. If a path...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Insects |
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| Online Access: | https://www.mdpi.com/2075-4450/8/3/85 |
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| author | Pedro Negri Leonor Ramirez Silvina Quintana Nicolás Szawarski Matías Maggi Yves Le Conte Lorenzo Lamattina Martin Eguaras |
| author_facet | Pedro Negri Leonor Ramirez Silvina Quintana Nicolás Szawarski Matías Maggi Yves Le Conte Lorenzo Lamattina Martin Eguaras |
| author_sort | Pedro Negri |
| collection | DOAJ |
| description | Many biotic and abiotic stressors impact bees’ health, acting as immunosupressors and contribute to colony losses. Thus, the importance of studying the immune response of honey bees is central to develop new strategies aiming to enhance bees’ fitness to confront the threats affecting them. If a pathogen breaches the physical and chemical barriers, honey bees can protect themselves from infection with cellular and humoral immune responses which represent a second line of defense. Through a series of correlative studies we have previously reported that abscisic acid (ABA) and nitric oxide (NO) share roles in the same immune defenses of Apis mellifera (A. mellifera). Here we show results supporting that the supplementation of bee larvae’s diet reared in vitro with l-Arginine (precursor of NO) or ABA enhanced the immune activation of the granulocytes in response to wounding and lipopolysaccharide (LPS) injection. |
| first_indexed | 2024-12-23T05:57:27Z |
| format | Article |
| id | doaj.art-c29feede1ca646ea8fe99dfd1dd97915 |
| institution | Directory Open Access Journal |
| issn | 2075-4450 |
| language | English |
| last_indexed | 2024-12-23T05:57:27Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj.art-c29feede1ca646ea8fe99dfd1dd979152022-12-21T17:57:46ZengMDPI AGInsects2075-44502017-08-01838510.3390/insects8030085insects8030085Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after TraumaPedro Negri0Leonor Ramirez1Silvina Quintana2Nicolás Szawarski3Matías Maggi4Yves Le Conte5Lorenzo Lamattina6Martin Eguaras7Centro de Investigación en Abejas Sociales (CIAS), Universidad Nacional de Mar del Plata (UNMdP), Dean Funes 3350, Mar del Plata CP 7600, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Godoy Cruz 2290, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Godoy Cruz 2290, ArgentinaCentro de Investigación en Abejas Sociales (CIAS), Universidad Nacional de Mar del Plata (UNMdP), Dean Funes 3350, Mar del Plata CP 7600, ArgentinaCentro de Investigación en Abejas Sociales (CIAS), Universidad Nacional de Mar del Plata (UNMdP), Dean Funes 3350, Mar del Plata CP 7600, ArgentinaINRA Centre de Recherche Provence-Alpes-Côted’Azur, Unitè Abeilles et Environnement, UMR PrADE, Domaine Saint Paul, Site Agroparc, Avignon F-84914, FranceConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Godoy Cruz 2290, ArgentinaCentro de Investigación en Abejas Sociales (CIAS), Universidad Nacional de Mar del Plata (UNMdP), Dean Funes 3350, Mar del Plata CP 7600, ArgentinaMany biotic and abiotic stressors impact bees’ health, acting as immunosupressors and contribute to colony losses. Thus, the importance of studying the immune response of honey bees is central to develop new strategies aiming to enhance bees’ fitness to confront the threats affecting them. If a pathogen breaches the physical and chemical barriers, honey bees can protect themselves from infection with cellular and humoral immune responses which represent a second line of defense. Through a series of correlative studies we have previously reported that abscisic acid (ABA) and nitric oxide (NO) share roles in the same immune defenses of Apis mellifera (A. mellifera). Here we show results supporting that the supplementation of bee larvae’s diet reared in vitro with l-Arginine (precursor of NO) or ABA enhanced the immune activation of the granulocytes in response to wounding and lipopolysaccharide (LPS) injection.https://www.mdpi.com/2075-4450/8/3/85Apis melliferaabscisic acidnitric oxideimmune response |
| spellingShingle | Pedro Negri Leonor Ramirez Silvina Quintana Nicolás Szawarski Matías Maggi Yves Le Conte Lorenzo Lamattina Martin Eguaras Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma Insects Apis mellifera abscisic acid nitric oxide immune response |
| title | Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma |
| title_full | Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma |
| title_fullStr | Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma |
| title_full_unstemmed | Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma |
| title_short | Dietary Supplementation of Honey Bee Larvae with Arginine and Abscisic Acid Enhances Nitric Oxide and Granulocyte Immune Responses after Trauma |
| title_sort | dietary supplementation of honey bee larvae with arginine and abscisic acid enhances nitric oxide and granulocyte immune responses after trauma |
| topic | Apis mellifera abscisic acid nitric oxide immune response |
| url | https://www.mdpi.com/2075-4450/8/3/85 |
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