Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows
Milk production and body conformation traits are critical economic traits for dairy cows. To understand the basic genetic structure for those traits, a genome wide association study was performed on milk yield, milk fat yield, milk fat percentage, milk protein yield, milk protein percentage, somatic...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.932034/full |
| _version_ | 1811238532380884992 |
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| author | Peng Wang Xue Li Xue Li Yihao Zhu Jiani Wei Chaoxin Zhang Chaoxin Zhang Qingfang Kong Xu Nie Qi Zhang Zhipeng Wang Zhipeng Wang |
| author_facet | Peng Wang Xue Li Xue Li Yihao Zhu Jiani Wei Chaoxin Zhang Chaoxin Zhang Qingfang Kong Xu Nie Qi Zhang Zhipeng Wang Zhipeng Wang |
| author_sort | Peng Wang |
| collection | DOAJ |
| description | Milk production and body conformation traits are critical economic traits for dairy cows. To understand the basic genetic structure for those traits, a genome wide association study was performed on milk yield, milk fat yield, milk fat percentage, milk protein yield, milk protein percentage, somatic cell score, body form composite index, daily capacity composite index, feed, and leg conformation traits, based on the Illumina Bovine HD100k BeadChip. A total of 57, 12 and 26 SNPs were found to be related to the milk production, somatic cell score and body conformation traits in the Holstein cattle. Genes with pleiotropic effect were also found in this study. Seven significant SNPs were associated with multi-traits and were located on the PLEC, PLEKHA5, TONSL, PTGER4, and LCORL genes. In addition, some important candidate genes, like GPAT3, CEBPB, AGO2, SLC37A1, and FNDC3B, were found to participate in fat metabolism or mammary gland development. These results can be used as candidate genes for milk production, somatic cell score, and body conformation traits of Holstein cows, and are helpful for further gene function analysis to improve milk production and quality. |
| first_indexed | 2024-04-12T12:43:13Z |
| format | Article |
| id | doaj.art-c2a11ef0f5724bb2b81a4afa33274d8f |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T12:43:13Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-c2a11ef0f5724bb2b81a4afa33274d8f2022-12-22T03:32:43ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-10-01910.3389/fvets.2022.932034932034Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cowsPeng Wang0Xue Li1Xue Li2Yihao Zhu3Jiani Wei4Chaoxin Zhang5Chaoxin Zhang6Qingfang Kong7Xu Nie8Qi Zhang9Zhipeng Wang10Zhipeng Wang11Heilongjiang Animal Husbandry Service, Harbin, ChinaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, ChinaBioinformatics Center, Northeast Agricultural University, Harbin, ChinaHeilongjiang Animal Husbandry Service, Harbin, ChinaSchool of mathematics, University of Edinburgh, Edinburgh, United KingdomCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, ChinaBioinformatics Center, Northeast Agricultural University, Harbin, ChinaHeilongjiang Animal Husbandry Service, Harbin, ChinaHeilongjiang Animal Husbandry Service, Harbin, ChinaCollege of Animal Science and Technology, China Agricultural University, Beijing, ChinaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, ChinaBioinformatics Center, Northeast Agricultural University, Harbin, ChinaMilk production and body conformation traits are critical economic traits for dairy cows. To understand the basic genetic structure for those traits, a genome wide association study was performed on milk yield, milk fat yield, milk fat percentage, milk protein yield, milk protein percentage, somatic cell score, body form composite index, daily capacity composite index, feed, and leg conformation traits, based on the Illumina Bovine HD100k BeadChip. A total of 57, 12 and 26 SNPs were found to be related to the milk production, somatic cell score and body conformation traits in the Holstein cattle. Genes with pleiotropic effect were also found in this study. Seven significant SNPs were associated with multi-traits and were located on the PLEC, PLEKHA5, TONSL, PTGER4, and LCORL genes. In addition, some important candidate genes, like GPAT3, CEBPB, AGO2, SLC37A1, and FNDC3B, were found to participate in fat metabolism or mammary gland development. These results can be used as candidate genes for milk production, somatic cell score, and body conformation traits of Holstein cows, and are helpful for further gene function analysis to improve milk production and quality.https://www.frontiersin.org/articles/10.3389/fvets.2022.932034/fullmilk production traitsbody conformation traitspleiotropic effectgenome-wide association studyHolstein cattle |
| spellingShingle | Peng Wang Xue Li Xue Li Yihao Zhu Jiani Wei Chaoxin Zhang Chaoxin Zhang Qingfang Kong Xu Nie Qi Zhang Zhipeng Wang Zhipeng Wang Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows Frontiers in Veterinary Science milk production traits body conformation traits pleiotropic effect genome-wide association study Holstein cattle |
| title | Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows |
| title_full | Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows |
| title_fullStr | Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows |
| title_full_unstemmed | Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows |
| title_short | Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows |
| title_sort | genome wide association analysis of milk production somatic cell score and body conformation traits in holstein cows |
| topic | milk production traits body conformation traits pleiotropic effect genome-wide association study Holstein cattle |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.932034/full |
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