Levetiracetam Reduced the Basal Excitability of the Dentate Gyrus without Restoring Impaired Synaptic Plasticity in Rats with Temporal Lobe Epilepsy

Levetiracetam Reduced the Basal Excitability of the Dentate Gyrus without Restoring Impaired Synaptic Plasticity in Rats with Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE), the most common type of focal epilepsy, affects learning and memory; these effects are thought to emerge from changes in synaptic plasticity. Levetiracetam (LEV) is a widely used antiepileptic drug that is also associated with the reversal of cognitive dysfunction. The...

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Bibliographic Details
Main Authors: Guillermo González-H, Itzel Jatziri Contreras-García, Karla Sánchez-Huerta, Claudio M. T. Queiroz, Luis Ricardo Gallardo Gudiño, Julieta G. Mendoza-Torreblanca, Sergio R. Zamudio
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Brain Sciences
Subjects:
inhibitory transmission
synaptic plasticity
temporal lobe epilepsy
evoked field potentials
levetiracetam
Online Access:https://www.mdpi.com/2076-3425/10/9/634

Internet

https://www.mdpi.com/2076-3425/10/9/634

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