| Summary: | Objective To evaluate the effect and adverse effects of concentrated growth factors coating in the treatment of stable segmental vitiligo with autologous epidermal transplantation. Methods Sixty-five patients with facial segmental vitiligo were randomized into the treatment group (n=33) and the control group (n=32). All patients underwent autologous epidermal transplantation. In the treatment group, the grafted area was covered with autologous epidermis, then covered with concentrated growth factors coating. Finally, vaseline gauze was used to cover the grafted area, and the gauze was pressure bandaged. In the control group the grafted area was only dressed with Vaseline gauze, and the gauze was pressure bandaged. All patients received 308 nm excimer light and topical 0.1% tacrolimus ointment beginning at 2 weeks after surgery. Postoperatively, patients were scheduled for routine follow-up to six months. Results After 6 months treatment, the effective rates for patients in the treatment group and in the control group were 93.94% and 75.0%, respectively, with significant difference between the groups (χ2=12.44, P=0.040). The incidence of pigmentation for patients in the treatment group and in the control group was 9.09% and 31.25%, respectively, with significant difference between the groups (χ2=4.99, P=0.026). The incidence of halo phenomenon for patients in the treatment group and in the control group was 15.15% and 37.50%, respectively, with significant difference between the groups (χ2=4.20, P=0.040). The incidence of infection for patients in the treatment group and in the control group was 3.03% and 6.06%, respectively, with no significant difference between two groups (χ2<0.01, P=0.978). Conclusion The use of concentrated growth factors coating for autologous epidermal transplantation in stable segmental vitiligo patients is feasible, safe, and effective.
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