Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy
The tumor microenvironment is complex and changeable, so the design of a nano-delivery system for the tumor microenvironment has attracted wide attention. Based on this, we designed an intelligent nano-reactor for the characteristics of acidic pH and hypoxia in the tumor microenvironment. Firstly, t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
|
| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221095670 |
| _version_ | 1811242452244234240 |
|---|---|
| author | Shuangxia Zhang PhD Yan Liu Bo Liu PhD |
| author_facet | Shuangxia Zhang PhD Yan Liu Bo Liu PhD |
| author_sort | Shuangxia Zhang PhD |
| collection | DOAJ |
| description | The tumor microenvironment is complex and changeable, so the design of a nano-delivery system for the tumor microenvironment has attracted wide attention. Based on this, we designed an intelligent nano-reactor for the characteristics of acidic pH and hypoxia in the tumor microenvironment. Firstly, the silver nano-balls were synthesized by the biological template method, which exhibited a good photothermal conversion efficiency and can realize the photothermal treatment of tumor sites. Subsequently, the hypoxic prodrug tirapazamine (TPZ) and polydopamine (PDA) for chemotherapy were self-assembled. After PDA arrived at the tumor site (pH 5.5) from the normal physiological environment (pH 7.4), the hypoxic prodrug TPZ was released in pH response by PDA. Subsequently, TPZ selectively induced obvious cell damage under tumor hypoxia stimulation but had no toxic effect on normal cells under normal oxygen. In addition, the nano-converter was loaded with iRGD on the surface, which enhanced the targeted delivery of the nano-reactor to achieve a highly effective antitumor effect. The nano-reactor was capable of combining photothermal/chemotherapy therapy. Importantly, it can selectively kill tumor cells without damaging normal cells based on the characteristics of the tumor microenvironment, with high bio-safety and clinical transformation potential. |
| first_indexed | 2024-04-12T13:51:28Z |
| format | Article |
| id | doaj.art-c2a5135e1b7a424099d24eacc921b68a |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-12T13:51:28Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-c2a5135e1b7a424099d24eacc921b68a2022-12-22T03:30:31ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-06-012110.1177/15330338221095670Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor TherapyShuangxia Zhang PhD0Yan Liu1Bo Liu PhD2 , Tianjin, China Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai, China , Shenyang, ChinaThe tumor microenvironment is complex and changeable, so the design of a nano-delivery system for the tumor microenvironment has attracted wide attention. Based on this, we designed an intelligent nano-reactor for the characteristics of acidic pH and hypoxia in the tumor microenvironment. Firstly, the silver nano-balls were synthesized by the biological template method, which exhibited a good photothermal conversion efficiency and can realize the photothermal treatment of tumor sites. Subsequently, the hypoxic prodrug tirapazamine (TPZ) and polydopamine (PDA) for chemotherapy were self-assembled. After PDA arrived at the tumor site (pH 5.5) from the normal physiological environment (pH 7.4), the hypoxic prodrug TPZ was released in pH response by PDA. Subsequently, TPZ selectively induced obvious cell damage under tumor hypoxia stimulation but had no toxic effect on normal cells under normal oxygen. In addition, the nano-converter was loaded with iRGD on the surface, which enhanced the targeted delivery of the nano-reactor to achieve a highly effective antitumor effect. The nano-reactor was capable of combining photothermal/chemotherapy therapy. Importantly, it can selectively kill tumor cells without damaging normal cells based on the characteristics of the tumor microenvironment, with high bio-safety and clinical transformation potential.https://doi.org/10.1177/15330338221095670 |
| spellingShingle | Shuangxia Zhang PhD Yan Liu Bo Liu PhD Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy Technology in Cancer Research & Treatment |
| title | Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy |
| title_full | Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy |
| title_fullStr | Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy |
| title_full_unstemmed | Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy |
| title_short | Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy |
| title_sort | highly active nano reactor for responding tumor microenvironment and antitumor therapy |
| url | https://doi.org/10.1177/15330338221095670 |
| work_keys_str_mv | AT shuangxiazhangphd highlyactivenanoreactorforrespondingtumormicroenvironmentandantitumortherapy AT yanliu highlyactivenanoreactorforrespondingtumormicroenvironmentandantitumortherapy AT boliuphd highlyactivenanoreactorforrespondingtumormicroenvironmentandantitumortherapy |