Training drives turnover rates in racehorse proximal sesamoid bones
Abstract Focal bone lesions are often found prior to clinically relevant stress-fractures. Lesions are characterized by low bone volume fraction, low mineral density, and high levels of microdamage and are hypothesized to develop when bone tissue cannot sufficiently respond to damaging loading. It i...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26027-y |
| _version_ | 1811175899404435456 |
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| author | Sarah K. Shaffer Susan M. Stover David P. Fyhrie |
| author_facet | Sarah K. Shaffer Susan M. Stover David P. Fyhrie |
| author_sort | Sarah K. Shaffer |
| collection | DOAJ |
| description | Abstract Focal bone lesions are often found prior to clinically relevant stress-fractures. Lesions are characterized by low bone volume fraction, low mineral density, and high levels of microdamage and are hypothesized to develop when bone tissue cannot sufficiently respond to damaging loading. It is difficult to determine how exercise drives the formation of these lesions because bone responds to mechanical loading and repairs damage. In this study, we derive steady-state rate constants for a compartment model of bone turnover using morphometric data from fractured and non-fractured racehorse proximal sesamoid bones (PSBs) and relate rate constants to racing-speed exercise data. Fractured PSBs had a subchondral focus of bone turnover and microdamage typical of lesions that develop prior to fracture. We determined steady-state model rate constants at the lesion site and an internal region without microdamage using bone volume fraction, tissue mineral density, and microdamage area fraction measurements. The derived undamaged bone resorption rate, damage formation rate, and osteoid formation rate had significant robust regression relationships to exercise intensity (rate) variables, layup (time out of exercise), and exercise 2–10 months before death. However, the direction of these relationships varied between the damaged (lesion) and non-damaged regions, reflecting that the biological response to damaging-loading differs from the response to non-damaging loading. |
| first_indexed | 2024-04-10T19:43:27Z |
| format | Article |
| id | doaj.art-c2a5a6db067049caa740fffa52b3688a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T19:43:27Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c2a5a6db067049caa740fffa52b3688a2023-01-29T12:11:07ZengNature PortfolioScientific Reports2045-23222023-01-0113111210.1038/s41598-022-26027-yTraining drives turnover rates in racehorse proximal sesamoid bonesSarah K. Shaffer0Susan M. Stover1David P. Fyhrie2Department of Orthopaedic Surgery, School of Medicine, University of CaliforniaDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of CaliforniaDepartment of Orthopaedic Surgery, School of Medicine, University of CaliforniaAbstract Focal bone lesions are often found prior to clinically relevant stress-fractures. Lesions are characterized by low bone volume fraction, low mineral density, and high levels of microdamage and are hypothesized to develop when bone tissue cannot sufficiently respond to damaging loading. It is difficult to determine how exercise drives the formation of these lesions because bone responds to mechanical loading and repairs damage. In this study, we derive steady-state rate constants for a compartment model of bone turnover using morphometric data from fractured and non-fractured racehorse proximal sesamoid bones (PSBs) and relate rate constants to racing-speed exercise data. Fractured PSBs had a subchondral focus of bone turnover and microdamage typical of lesions that develop prior to fracture. We determined steady-state model rate constants at the lesion site and an internal region without microdamage using bone volume fraction, tissue mineral density, and microdamage area fraction measurements. The derived undamaged bone resorption rate, damage formation rate, and osteoid formation rate had significant robust regression relationships to exercise intensity (rate) variables, layup (time out of exercise), and exercise 2–10 months before death. However, the direction of these relationships varied between the damaged (lesion) and non-damaged regions, reflecting that the biological response to damaging-loading differs from the response to non-damaging loading.https://doi.org/10.1038/s41598-022-26027-y |
| spellingShingle | Sarah K. Shaffer Susan M. Stover David P. Fyhrie Training drives turnover rates in racehorse proximal sesamoid bones Scientific Reports |
| title | Training drives turnover rates in racehorse proximal sesamoid bones |
| title_full | Training drives turnover rates in racehorse proximal sesamoid bones |
| title_fullStr | Training drives turnover rates in racehorse proximal sesamoid bones |
| title_full_unstemmed | Training drives turnover rates in racehorse proximal sesamoid bones |
| title_short | Training drives turnover rates in racehorse proximal sesamoid bones |
| title_sort | training drives turnover rates in racehorse proximal sesamoid bones |
| url | https://doi.org/10.1038/s41598-022-26027-y |
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