Advances in the study of RNA-binding proteins in diabetic complications
Background: It has been reported that diabetes mellitus affects 435 million people globally as a primary health care problem. Despite many therapies available, many diabetes remains uncontrolled, giving rise to irreversible diabetic complications that pose significant risks to patients’ wellbeing an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
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| Series: | Molecular Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877822000849 |
| _version_ | 1818466440283422720 |
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| author | Xinyue Chen Jiaqiang Wu Zhangwang Li Jiashu Han Panpan Xia Yunfeng Shen Jianyong Ma Xiao Liu Jing Zhang Peng Yu |
| author_facet | Xinyue Chen Jiaqiang Wu Zhangwang Li Jiashu Han Panpan Xia Yunfeng Shen Jianyong Ma Xiao Liu Jing Zhang Peng Yu |
| author_sort | Xinyue Chen |
| collection | DOAJ |
| description | Background: It has been reported that diabetes mellitus affects 435 million people globally as a primary health care problem. Despite many therapies available, many diabetes remains uncontrolled, giving rise to irreversible diabetic complications that pose significant risks to patients’ wellbeing and survival. Scope of Review: In recent years, as much effort is put into elucidating the posttranscriptional gene regulation network of diabetes and diabetic complications; RNA binding proteins (RBPs) are found to be vital. RBPs regulate gene expression through various post-transcriptional mechanisms, including alternative splicing, RNA export, messenger RNA translation, RNA degradation, and RNA stabilization. Major Conclusions: Here, we summarized recent studies on the roles and mechanisms of RBPs in mediating abnormal gene expression in diabetes and its complications. Moreover, we discussed the potential and theoretical basis of RBPs to treat diabetes and its complications. |
| first_indexed | 2024-04-13T20:58:24Z |
| format | Article |
| id | doaj.art-c2a5ac6879d04b32be359a90206bda6f |
| institution | Directory Open Access Journal |
| issn | 2212-8778 |
| language | English |
| last_indexed | 2024-04-13T20:58:24Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj.art-c2a5ac6879d04b32be359a90206bda6f2022-12-22T02:30:14ZengElsevierMolecular Metabolism2212-87782022-08-0162101515Advances in the study of RNA-binding proteins in diabetic complicationsXinyue Chen0Jiaqiang Wu1Zhangwang Li2Jiashu Han3Panpan Xia4Yunfeng Shen5Jianyong Ma6Xiao Liu7Jing Zhang8Peng Yu9The Second Clinical Medical College of Nanchang University, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Thoracic Surgery, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Metabolism and Endocrinology, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Metabolism and Endocrinology, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, USADepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaThe Second Clinical Medical College of Nanchang University, the Second Affiliated Hospital of Nanchang University, Nanchang, China; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Jiangxi, Nanchang 330006, China; Corresponding author. Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.The Second Clinical Medical College of Nanchang University, the Second Affiliated Hospital of Nanchang University, Nanchang, China; Department of Metabolism and Endocrinology, the Second Affiliated Hospital of Nanchang University, Nanchang, China; Corresponding author. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.Background: It has been reported that diabetes mellitus affects 435 million people globally as a primary health care problem. Despite many therapies available, many diabetes remains uncontrolled, giving rise to irreversible diabetic complications that pose significant risks to patients’ wellbeing and survival. Scope of Review: In recent years, as much effort is put into elucidating the posttranscriptional gene regulation network of diabetes and diabetic complications; RNA binding proteins (RBPs) are found to be vital. RBPs regulate gene expression through various post-transcriptional mechanisms, including alternative splicing, RNA export, messenger RNA translation, RNA degradation, and RNA stabilization. Major Conclusions: Here, we summarized recent studies on the roles and mechanisms of RBPs in mediating abnormal gene expression in diabetes and its complications. Moreover, we discussed the potential and theoretical basis of RBPs to treat diabetes and its complications.http://www.sciencedirect.com/science/article/pii/S2212877822000849DiabetesDiabetic complicationsRNA binding proteinsTherapy |
| spellingShingle | Xinyue Chen Jiaqiang Wu Zhangwang Li Jiashu Han Panpan Xia Yunfeng Shen Jianyong Ma Xiao Liu Jing Zhang Peng Yu Advances in the study of RNA-binding proteins in diabetic complications Molecular Metabolism Diabetes Diabetic complications RNA binding proteins Therapy |
| title | Advances in the study of RNA-binding proteins in diabetic complications |
| title_full | Advances in the study of RNA-binding proteins in diabetic complications |
| title_fullStr | Advances in the study of RNA-binding proteins in diabetic complications |
| title_full_unstemmed | Advances in the study of RNA-binding proteins in diabetic complications |
| title_short | Advances in the study of RNA-binding proteins in diabetic complications |
| title_sort | advances in the study of rna binding proteins in diabetic complications |
| topic | Diabetes Diabetic complications RNA binding proteins Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2212877822000849 |
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