Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice

Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice

Senolytics are a class of drugs that selectively eliminate senescent cells and ameliorate senescence-associated disease. Studies have demonstrated the accumulation of senescent disc cells and the production of senescence-associated secretory phenotype decrease the number of functional cells in degen...

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Bibliographic Details
Main Authors: Bolin Chen, Runjiu Zhu, Hao Hu, Mingbin Zhan, Tingxuan Wang, Fangli Huang, Fuxin Wei, Yu Chai, Zemin Ling, Xuenong Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intervertebral disc degeneration
aging
senescence
senolytics
bony endplate
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.853688/full

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