Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance
Abstract Background Collision and composite carcinomas of the thyroid are extremely rare, and their clinical and biological characteristics are poorly understood. Case presentation The first case was a 41-year-old female patient with a right thyroid nodule. Pathological diagnosis was papillary thyro...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-023-01409-z |
| _version_ | 1797559134227267584 |
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| author | Tao Ma Ruixiao Wang Xu Zhou Liqiang Liu Aijing Pan Hongmei Wang Lingyan Huang |
| author_facet | Tao Ma Ruixiao Wang Xu Zhou Liqiang Liu Aijing Pan Hongmei Wang Lingyan Huang |
| author_sort | Tao Ma |
| collection | DOAJ |
| description | Abstract Background Collision and composite carcinomas of the thyroid are extremely rare, and their clinical and biological characteristics are poorly understood. Case presentation The first case was a 41-year-old female patient with a right thyroid nodule. Pathological diagnosis was papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma composite carcinoma. Surgical treatment was right thyroid lobectomy + left partial thyroidectomy + right central neck lymph node dissection. The second case was a 60-year-old female with bilateral thyroid nodules. Total thyroidectomy was performed, and the pathological diagnosis was thyroid collision carcinoma involving follicular thyroid carcinoma on the left side and PTC on the right side. Summary The clinical, histological and gene changes of collision and composite carcinomas of the thyroid are poorly described. With different biological invasion characteristics, the ideal treatment and the prognosis is currently unknown and individualized treatment is necessary. Conclusions It is recommended that in composite carcinoma, each cancer is evaluated and treated according to the most severe tumor. Collision carcinoma should be treated as two separate synchronous primary tumors. For both collision and composite carcinomas of the thyroid, the follow-up after treatment should be extensive. |
| first_indexed | 2024-03-10T17:41:07Z |
| format | Article |
| id | doaj.art-c2a9da70ea5c41a09fd7ccb4885e70d7 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-10T17:41:07Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-c2a9da70ea5c41a09fd7ccb4885e70d72023-11-20T09:42:06ZengBMCBMC Endocrine Disorders1472-68232023-08-012311710.1186/s12902-023-01409-zCase reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significanceTao Ma0Ruixiao Wang1Xu Zhou2Liqiang Liu3Aijing Pan4Hongmei Wang5Lingyan Huang6Surgical Oncology, General Hospital of Ningxia Medical UniversityPathological Department, General Hospital of Ningxia Medical UniversityUltrosound Department, General Hospital of Ningxia Medical University, Ningxia ProvinceSurgical Oncology, General Hospital of Ningxia Medical UniversityClinical Medical College, Ningxia Medical UniversityDepartment of Pharmacology, School of Medicine, Southeast UniversityPathological Department, General Hospital of Ningxia Medical UniversityAbstract Background Collision and composite carcinomas of the thyroid are extremely rare, and their clinical and biological characteristics are poorly understood. Case presentation The first case was a 41-year-old female patient with a right thyroid nodule. Pathological diagnosis was papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma composite carcinoma. Surgical treatment was right thyroid lobectomy + left partial thyroidectomy + right central neck lymph node dissection. The second case was a 60-year-old female with bilateral thyroid nodules. Total thyroidectomy was performed, and the pathological diagnosis was thyroid collision carcinoma involving follicular thyroid carcinoma on the left side and PTC on the right side. Summary The clinical, histological and gene changes of collision and composite carcinomas of the thyroid are poorly described. With different biological invasion characteristics, the ideal treatment and the prognosis is currently unknown and individualized treatment is necessary. Conclusions It is recommended that in composite carcinoma, each cancer is evaluated and treated according to the most severe tumor. Collision carcinoma should be treated as two separate synchronous primary tumors. For both collision and composite carcinomas of the thyroid, the follow-up after treatment should be extensive.https://doi.org/10.1186/s12902-023-01409-zCase reportCollision carcinomaComposite carcinomaThyroid |
| spellingShingle | Tao Ma Ruixiao Wang Xu Zhou Liqiang Liu Aijing Pan Hongmei Wang Lingyan Huang Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance BMC Endocrine Disorders Case report Collision carcinoma Composite carcinoma Thyroid |
| title | Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance |
| title_full | Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance |
| title_fullStr | Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance |
| title_full_unstemmed | Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance |
| title_short | Case reports of collision and composite carcinomas of the thyroid: an insight into their origin and clinical significance |
| title_sort | case reports of collision and composite carcinomas of the thyroid an insight into their origin and clinical significance |
| topic | Case report Collision carcinoma Composite carcinoma Thyroid |
| url | https://doi.org/10.1186/s12902-023-01409-z |
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