p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells.

p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells.

BACKGROUND: p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether and how p53 influences the transformation from tetraploidy to aneuploidy. PRINCIPAL...

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Bibliographic Details
Main Authors: Qiyi Yi, Xiaoyu Zhao, Yun Huang, Tieliang Ma, Yingyin Zhang, Heli Hou, Howard J Cooke, Da-Qing Yang, Mian Wu, Qinghua Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3208627?pdf=render

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