Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer
Flavonoids are the largest group of polyphenols, represented by many compounds that exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin, isoquercitrin, isorhamnetin, tamarixetin, rhamnetin, and hyperoside) in the class of flavonols have been documented to ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/20/15208 |
| _version_ | 1797573650210095104 |
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| author | Naser A. Alsharairi |
| author_facet | Naser A. Alsharairi |
| author_sort | Naser A. Alsharairi |
| collection | DOAJ |
| description | Flavonoids are the largest group of polyphenols, represented by many compounds that exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin, isoquercitrin, isorhamnetin, tamarixetin, rhamnetin, and hyperoside) in the class of flavonols have been documented to exert anticancer activity. Q has been shown to be useful in the treatment of non-small cell lung cancer (NSCLC), as demonstrated by in vitro/in vivo studies, due to its antitumor, anti-inflammatory, anti-proliferative, anti-angiogenesis, and apoptotic properties. Some flavonoids (flavone, anthocyanins, and proanthocyanidins) have been demonstrated to be effective in nicotine-induced NSCLC treatment. However, the molecular mechanisms of quercetin derivatives (QDs) in nicotine-induced NSCLC treatment remain unclear. Thus, this review aims to summarize the available literature on the therapeutic effects of QDs in nicotine-induced NSCLC. |
| first_indexed | 2024-03-10T21:12:08Z |
| format | Article |
| id | doaj.art-c2ab19ed11e04814b81818d9c4e72190 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:12:08Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c2ab19ed11e04814b81818d9c4e721902023-11-19T16:43:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201520810.3390/ijms242015208Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung CancerNaser A. Alsharairi0Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, AustraliaFlavonoids are the largest group of polyphenols, represented by many compounds that exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin, isoquercitrin, isorhamnetin, tamarixetin, rhamnetin, and hyperoside) in the class of flavonols have been documented to exert anticancer activity. Q has been shown to be useful in the treatment of non-small cell lung cancer (NSCLC), as demonstrated by in vitro/in vivo studies, due to its antitumor, anti-inflammatory, anti-proliferative, anti-angiogenesis, and apoptotic properties. Some flavonoids (flavone, anthocyanins, and proanthocyanidins) have been demonstrated to be effective in nicotine-induced NSCLC treatment. However, the molecular mechanisms of quercetin derivatives (QDs) in nicotine-induced NSCLC treatment remain unclear. Thus, this review aims to summarize the available literature on the therapeutic effects of QDs in nicotine-induced NSCLC.https://www.mdpi.com/1422-0067/24/20/15208flavonoidsflavonolsquercetin derivativesnon-small cell lung cancernicotinemolecular mechanisms |
| spellingShingle | Naser A. Alsharairi Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer International Journal of Molecular Sciences flavonoids flavonols quercetin derivatives non-small cell lung cancer nicotine molecular mechanisms |
| title | Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer |
| title_full | Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer |
| title_fullStr | Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer |
| title_full_unstemmed | Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer |
| title_short | Quercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer |
| title_sort | quercetin derivatives as potential therapeutic agents an updated perspective on the treatment of nicotine induced non small cell lung cancer |
| topic | flavonoids flavonols quercetin derivatives non-small cell lung cancer nicotine molecular mechanisms |
| url | https://www.mdpi.com/1422-0067/24/20/15208 |
| work_keys_str_mv | AT naseraalsharairi quercetinderivativesaspotentialtherapeuticagentsanupdatedperspectiveonthetreatmentofnicotineinducednonsmallcelllungcancer |