Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer
Generic quality of life (QoL) is an important issue in decision making related to the primary treatment of localized prostate cancer (PC). This study assessed the dynamic changes of QoL in patients with localized PC under different treatment modalities. From 2013 to 2018, we prospectively assessed Q...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/1/158 |
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| author | Yao-Lin Kao Chien-Hui Ou Sheng-Hsiang Lin Sheng-Mao Chang Jung-Der Wang Yuh-Shyan Tsai |
| author_facet | Yao-Lin Kao Chien-Hui Ou Sheng-Hsiang Lin Sheng-Mao Chang Jung-Der Wang Yuh-Shyan Tsai |
| author_sort | Yao-Lin Kao |
| collection | DOAJ |
| description | Generic quality of life (QoL) is an important issue in decision making related to the primary treatment of localized prostate cancer (PC). This study assessed the dynamic changes of QoL in patients with localized PC under different treatment modalities. From 2013 to 2018, we prospectively assessed QoL scores in patients with localized PC under unitary treatment using the World Health Organization Quality of Life (WHOQOL) BREF version. The trajectories of the QoL scores after different treatments were estimated using a kernel-smoothing method. Dynamic changes in the major determinants were analyzed using a mixed effects model. The clinical features of the participants in our institute were compared with PC patients in Taiwan’s cancer registry. A total of 196 patients were enrolled with 491 repeated assessments. The participants shared similar clinical characteristics with the PC patients in Taiwan as a whole. Patients with lower household incomes showed statistically significant lower scores on all four domains and related facets, while PC survivors with comorbidities of anxiety and/or diabetes appeared to be affected on the physical domain and related facets. After controlling for these determinants, patients under active surveillance or observation demonstrated significantly higher QoL scores in the physical and social domains, as well as several facets belonging to these domains, in mixed models compared with patients undergoing radical prostatectomy or radiotherapy within the first year. The generic QoL scores were higher within the first year in patients receiving active surveillance or observation after controlling other significant factors. The difference diminished after one year of post management. More studies are needed to corroborate our findings. |
| first_indexed | 2024-03-10T13:29:22Z |
| format | Article |
| id | doaj.art-c2ac45087cac416aa3f1907f93b29432 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:29:22Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c2ac45087cac416aa3f1907f93b294322023-11-21T08:24:07ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110115810.3390/jcm10010158Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate CancerYao-Lin Kao0Chien-Hui Ou1Sheng-Hsiang Lin2Sheng-Mao Chang3Jung-Der Wang4Yuh-Shyan Tsai5Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Statistics, National Cheng Kung University, Tainan 701, TaiwanDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanGeneric quality of life (QoL) is an important issue in decision making related to the primary treatment of localized prostate cancer (PC). This study assessed the dynamic changes of QoL in patients with localized PC under different treatment modalities. From 2013 to 2018, we prospectively assessed QoL scores in patients with localized PC under unitary treatment using the World Health Organization Quality of Life (WHOQOL) BREF version. The trajectories of the QoL scores after different treatments were estimated using a kernel-smoothing method. Dynamic changes in the major determinants were analyzed using a mixed effects model. The clinical features of the participants in our institute were compared with PC patients in Taiwan’s cancer registry. A total of 196 patients were enrolled with 491 repeated assessments. The participants shared similar clinical characteristics with the PC patients in Taiwan as a whole. Patients with lower household incomes showed statistically significant lower scores on all four domains and related facets, while PC survivors with comorbidities of anxiety and/or diabetes appeared to be affected on the physical domain and related facets. After controlling for these determinants, patients under active surveillance or observation demonstrated significantly higher QoL scores in the physical and social domains, as well as several facets belonging to these domains, in mixed models compared with patients undergoing radical prostatectomy or radiotherapy within the first year. The generic QoL scores were higher within the first year in patients receiving active surveillance or observation after controlling other significant factors. The difference diminished after one year of post management. More studies are needed to corroborate our findings.https://www.mdpi.com/2077-0383/10/1/158prostate cancerquality of lifeprostatectomyradiotherapyactive surveillance |
| spellingShingle | Yao-Lin Kao Chien-Hui Ou Sheng-Hsiang Lin Sheng-Mao Chang Jung-Der Wang Yuh-Shyan Tsai Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer Journal of Clinical Medicine prostate cancer quality of life prostatectomy radiotherapy active surveillance |
| title | Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer |
| title_full | Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer |
| title_fullStr | Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer |
| title_full_unstemmed | Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer |
| title_short | Dynamic Changes of Generic Quality of Life after Different Treatments for Localized Prostate Cancer |
| title_sort | dynamic changes of generic quality of life after different treatments for localized prostate cancer |
| topic | prostate cancer quality of life prostatectomy radiotherapy active surveillance |
| url | https://www.mdpi.com/2077-0383/10/1/158 |
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