Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
Summary: To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422301413X |
| _version_ | 1797770771059179520 |
|---|---|
| author | Brendan Stiltner Robert H. Pietrzak Daniel S. Tylee Yaira Z. Nunez Keyrun Adhikari Henry R. Kranzler Joel Gelernter Renato Polimanti |
| author_facet | Brendan Stiltner Robert H. Pietrzak Daniel S. Tylee Yaira Z. Nunez Keyrun Adhikari Henry R. Kranzler Joel Gelernter Renato Polimanti |
| author_sort | Brendan Stiltner |
| collection | DOAJ |
| description | Summary: To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate, 38%; high, 45%). While these subgroups varied by age, sex, and racial-ethnic distribution (p < 0.001), there was no difference with respect to education or income (p > 0.05). After accounting for sex, age, and race-ethnicity, the CoUD subgroup with high PSA had higher odds of antisocial personality disorder (OR = 21.96 vs. 6.39, difference-p = 8.08✕10−6), agoraphobia (OR = 4.58 vs. 2.05, difference-p = 7.04✕10−4), mixed bipolar episode (OR = 10.36 vs. 2.61, difference-p = 7.04✕10−4), posttraumatic stress disorder (OR = 11.54 vs. 5.86, difference-p = 2.67✕10−4), antidepressant medication use (OR = 13.49 vs. 8.02, difference-p = 1.42✕10−4), and sexually transmitted diseases (OR = 5.92 vs. 3.38, difference-p = 1.81✕10−5) than the low-PSA CoUD subgroup. These findings underscore the importance of modeling PSA severity and comorbidities when examining the clinical, molecular, and neuroimaging correlates of CoUD. |
| first_indexed | 2024-03-12T21:28:00Z |
| format | Article |
| id | doaj.art-c2aecbf616f04aa380ab9bbc556c6079 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T21:28:00Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-c2aecbf616f04aa380ab9bbc556c60792023-07-28T04:26:31ZengElsevieriScience2589-00422023-08-01268107336Polysubstance addiction patterns among 7,989 individuals with cocaine use disorderBrendan Stiltner0Robert H. Pietrzak1Daniel S. Tylee2Yaira Z. Nunez3Keyrun Adhikari4Henry R. Kranzler5Joel Gelernter6Renato Polimanti7Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT 06516, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USAUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Mental Illness Research, Education, and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USA; Corresponding authorSummary: To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate, 38%; high, 45%). While these subgroups varied by age, sex, and racial-ethnic distribution (p < 0.001), there was no difference with respect to education or income (p > 0.05). After accounting for sex, age, and race-ethnicity, the CoUD subgroup with high PSA had higher odds of antisocial personality disorder (OR = 21.96 vs. 6.39, difference-p = 8.08✕10−6), agoraphobia (OR = 4.58 vs. 2.05, difference-p = 7.04✕10−4), mixed bipolar episode (OR = 10.36 vs. 2.61, difference-p = 7.04✕10−4), posttraumatic stress disorder (OR = 11.54 vs. 5.86, difference-p = 2.67✕10−4), antidepressant medication use (OR = 13.49 vs. 8.02, difference-p = 1.42✕10−4), and sexually transmitted diseases (OR = 5.92 vs. 3.38, difference-p = 1.81✕10−5) than the low-PSA CoUD subgroup. These findings underscore the importance of modeling PSA severity and comorbidities when examining the clinical, molecular, and neuroimaging correlates of CoUD.http://www.sciencedirect.com/science/article/pii/S258900422301413XAddiction medicineSocioeconomic status |
| spellingShingle | Brendan Stiltner Robert H. Pietrzak Daniel S. Tylee Yaira Z. Nunez Keyrun Adhikari Henry R. Kranzler Joel Gelernter Renato Polimanti Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder iScience Addiction medicine Socioeconomic status |
| title | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
| title_full | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
| title_fullStr | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
| title_full_unstemmed | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
| title_short | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
| title_sort | polysubstance addiction patterns among 7 989 individuals with cocaine use disorder |
| topic | Addiction medicine Socioeconomic status |
| url | http://www.sciencedirect.com/science/article/pii/S258900422301413X |
| work_keys_str_mv | AT brendanstiltner polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT roberthpietrzak polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT danielstylee polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT yairaznunez polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT keyrunadhikari polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT henryrkranzler polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT joelgelernter polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder AT renatopolimanti polysubstanceaddictionpatternsamong7989individualswithcocaineusedisorder |