DNA Interactions and Biological Activity of 2,9-Disubstituted 1,10-Phenanthroline Thiosemicarbazone-Based Ligands and a 4-Phenylthiazole Derivative

DNA Interactions and Biological Activity of 2,9-Disubstituted 1,10-Phenanthroline Thiosemicarbazone-Based Ligands and a 4-Phenylthiazole Derivative

Four 1,10-phenanthroline derivatives (<b>1</b>–<b>4</b>) were synthesized as potential telomeric DNA binders, three substituted in their chains with thiosemicarbazones (TSCs) and one 4-phenylthiazole derivative. The compounds were characterized using NMR, HRMS, FTIR-spectrosc...

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Bibliographic Details
Main Authors: Álvaro Nicolás, Julia G. Quero, Marta Barroso, Zoila Gándara, Lourdes Gude
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biology
Subjects:
thiosemicarbazones (TSCs)
1,10-phenanthroline
G4 DNA
antitumor agents
DNA interactions
Online Access:https://www.mdpi.com/2079-7737/13/1/60

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