Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy
Abstract Sonodynamic therapy (SDT) typically suffers from compromised anticancer efficacy owing to the low reactive oxygen species (ROS) yield and complicated tumor microenvironment (TME) which can consume ROS and support the occurrence and development of tumors. Herein, ultrathin‐FeOOH‐coated MnO2...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202200005 |
| _version_ | 1811248032017022976 |
|---|---|
| author | Qiyu Liu Liyin Shi Ying Liao Xianshuo Cao Xiaoqing Liu Yanxia Yu Zifan Wang Xihong Lu Jianwei Wang |
| author_facet | Qiyu Liu Liyin Shi Ying Liao Xianshuo Cao Xiaoqing Liu Yanxia Yu Zifan Wang Xihong Lu Jianwei Wang |
| author_sort | Qiyu Liu |
| collection | DOAJ |
| description | Abstract Sonodynamic therapy (SDT) typically suffers from compromised anticancer efficacy owing to the low reactive oxygen species (ROS) yield and complicated tumor microenvironment (TME) which can consume ROS and support the occurrence and development of tumors. Herein, ultrathin‐FeOOH‐coated MnO2 nanospheres (denoted as MO@FHO) as sonosensitizers which can not only facilitate ultrasound (US)‐triggered ROS but also tune the TME by hypoxia alleviation, H2O2 consumption as well as glutathione (GSH) depletion are designed. The FeOOH coating will boost the production yield of singlet oxygen (1O2) and hydroxyl radicals (•OH) by inhibiting the recombination of US‐initiated electron–hole pairs and Fenton‐like reaction, respectively. Additionally, the catalase‐like and GSH peroxidase‐like activities of MO@FHO nanospheres enable them to break the TME equilibrium via hypoxia alleviation and GSH depletion. The combination of high ROS yield and fundamental destruction of TME equilibrium results in satisfactory antitumor outcomes, as demonstrated by the high tumor suppression efficacy of MO@FHO on MDA‐MB‐231‐tumor‐bearing mice. No obvious toxicity is detected to normal tissues at therapeutic doses in vivo. The capability to modulate the ROS production and TME simultaneously can afford new probability for the development of advanced sonosensitizers for synergistic comprehensive cancer therapy. |
| first_indexed | 2024-04-12T15:19:55Z |
| format | Article |
| id | doaj.art-c2b336c98c8543cf86277bfedcbd6bab |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T15:19:55Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-c2b336c98c8543cf86277bfedcbd6bab2022-12-22T03:27:30ZengWileyAdvanced Science2198-38442022-06-01917n/an/a10.1002/advs.202200005Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer TherapyQiyu Liu0Liyin Shi1Ying Liao2Xianshuo Cao3Xiaoqing Liu4Yanxia Yu5Zifan Wang6Xihong Lu7Jianwei Wang8Sun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSun Yat‐Sen University Cancer Center State Key Lab oratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province School of Chemistry Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaAbstract Sonodynamic therapy (SDT) typically suffers from compromised anticancer efficacy owing to the low reactive oxygen species (ROS) yield and complicated tumor microenvironment (TME) which can consume ROS and support the occurrence and development of tumors. Herein, ultrathin‐FeOOH‐coated MnO2 nanospheres (denoted as MO@FHO) as sonosensitizers which can not only facilitate ultrasound (US)‐triggered ROS but also tune the TME by hypoxia alleviation, H2O2 consumption as well as glutathione (GSH) depletion are designed. The FeOOH coating will boost the production yield of singlet oxygen (1O2) and hydroxyl radicals (•OH) by inhibiting the recombination of US‐initiated electron–hole pairs and Fenton‐like reaction, respectively. Additionally, the catalase‐like and GSH peroxidase‐like activities of MO@FHO nanospheres enable them to break the TME equilibrium via hypoxia alleviation and GSH depletion. The combination of high ROS yield and fundamental destruction of TME equilibrium results in satisfactory antitumor outcomes, as demonstrated by the high tumor suppression efficacy of MO@FHO on MDA‐MB‐231‐tumor‐bearing mice. No obvious toxicity is detected to normal tissues at therapeutic doses in vivo. The capability to modulate the ROS production and TME simultaneously can afford new probability for the development of advanced sonosensitizers for synergistic comprehensive cancer therapy.https://doi.org/10.1002/advs.202200005manganese dioxidereactive oxygen speciessonodynamic therapysonosensitizerstumor microenvironment |
| spellingShingle | Qiyu Liu Liyin Shi Ying Liao Xianshuo Cao Xiaoqing Liu Yanxia Yu Zifan Wang Xihong Lu Jianwei Wang Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy Advanced Science manganese dioxide reactive oxygen species sonodynamic therapy sonosensitizers tumor microenvironment |
| title | Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy |
| title_full | Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy |
| title_fullStr | Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy |
| title_full_unstemmed | Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy |
| title_short | Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy |
| title_sort | ultrathin feooh coated mno2 sonosensitizers with boosted reactive oxygen species yield and remodeled tumor microenvironment for efficient cancer therapy |
| topic | manganese dioxide reactive oxygen species sonodynamic therapy sonosensitizers tumor microenvironment |
| url | https://doi.org/10.1002/advs.202200005 |
| work_keys_str_mv | AT qiyuliu ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT liyinshi ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT yingliao ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT xianshuocao ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT xiaoqingliu ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT yanxiayu ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT zifanwang ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT xihonglu ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy AT jianweiwang ultrathinfeoohcoatedmno2sonosensitizerswithboostedreactiveoxygenspeciesyieldandremodeledtumormicroenvironmentforefficientcancertherapy |