Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency.
<h4>Background</h4>Velopharyngeal structure augmentation methods are used as alternatives to pharyngeal flap operations. Recently, we investigated the sites of velopharyngeal structure augmentation in dogs and reported that the most effective injection location is the soft palate. Howeve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0238646 |
| _version_ | 1819140164819091456 |
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| author | Emiko Tanaka Isomura Makoto Matsukawa Kiyoko Nakagawa Ryo Mitsui Mikihiko Kogo |
| author_facet | Emiko Tanaka Isomura Makoto Matsukawa Kiyoko Nakagawa Ryo Mitsui Mikihiko Kogo |
| author_sort | Emiko Tanaka Isomura |
| collection | DOAJ |
| description | <h4>Background</h4>Velopharyngeal structure augmentation methods are used as alternatives to pharyngeal flap operations. Recently, we investigated the sites of velopharyngeal structure augmentation in dogs and reported that the most effective injection location is the soft palate. However, there have been no reports regarding the optimal materials for implantation or injection. In this study, we aimed to investigate the injectable materials used in soft palate augmentation in dogs to ameliorate velopharyngeal insufficiency (VPI).<h4>Methods</h4>Endoscopic soft palate augmentation (ESPA) was performed in dogs using purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. ESPA is an original technique developed by our group, and this is the first report of its performance. Moreover, we assessed the amount of nasal air leakage during inspiration at rest and during expiration under the rebreathing system at 1, 2, 3, 4, 5, and 6 months after injection of these materials.<h4>Results</h4>The amount of nasal air leakage during expiration under the rebreathing system was significantly decreased in all dogs injected with the ESPA materials, but neither apnea nor hypopnea was observed.<h4>Conclusions</h4>We investigated the optimal materials for use in ESPA, such as purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. We found that all of them reduced nasal air leakage and only autogenic fat tissue showed significant histologic differences in dogs at 6 months. This technique may also be useful for the treatment of patients with VPI. |
| first_indexed | 2024-12-22T11:34:13Z |
| format | Article |
| id | doaj.art-c2b3cefdea66410cb2ae208b2a22c96e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T11:34:13Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c2b3cefdea66410cb2ae208b2a22c96e2022-12-21T18:27:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159e023864610.1371/journal.pone.0238646Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency.Emiko Tanaka IsomuraMakoto MatsukawaKiyoko NakagawaRyo MitsuiMikihiko Kogo<h4>Background</h4>Velopharyngeal structure augmentation methods are used as alternatives to pharyngeal flap operations. Recently, we investigated the sites of velopharyngeal structure augmentation in dogs and reported that the most effective injection location is the soft palate. However, there have been no reports regarding the optimal materials for implantation or injection. In this study, we aimed to investigate the injectable materials used in soft palate augmentation in dogs to ameliorate velopharyngeal insufficiency (VPI).<h4>Methods</h4>Endoscopic soft palate augmentation (ESPA) was performed in dogs using purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. ESPA is an original technique developed by our group, and this is the first report of its performance. Moreover, we assessed the amount of nasal air leakage during inspiration at rest and during expiration under the rebreathing system at 1, 2, 3, 4, 5, and 6 months after injection of these materials.<h4>Results</h4>The amount of nasal air leakage during expiration under the rebreathing system was significantly decreased in all dogs injected with the ESPA materials, but neither apnea nor hypopnea was observed.<h4>Conclusions</h4>We investigated the optimal materials for use in ESPA, such as purified sodium hyaluronate, atelocollagen, or autogenic fat tissue. We found that all of them reduced nasal air leakage and only autogenic fat tissue showed significant histologic differences in dogs at 6 months. This technique may also be useful for the treatment of patients with VPI.https://doi.org/10.1371/journal.pone.0238646 |
| spellingShingle | Emiko Tanaka Isomura Makoto Matsukawa Kiyoko Nakagawa Ryo Mitsui Mikihiko Kogo Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. PLoS ONE |
| title | Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. |
| title_full | Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. |
| title_fullStr | Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. |
| title_full_unstemmed | Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. |
| title_short | Endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency. |
| title_sort | endoscopic soft palate augmentation using injectable materials in dogs to ameliorate velopharyngeal insufficiency |
| url | https://doi.org/10.1371/journal.pone.0238646 |
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