Desmosomes as Signaling Hubs in the Regulation of Cell Behavior
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to change cell behavior. Desmosome composition and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.745670/full |
| _version_ | 1818361523784908800 |
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| author | Lisa Müller Mechthild Hatzfeld René Keil |
| author_facet | Lisa Müller Mechthild Hatzfeld René Keil |
| author_sort | Lisa Müller |
| collection | DOAJ |
| description | Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to change cell behavior. Desmosome composition and size vary depending on tissue specific expression and differentiation state. Their constituent proteins are highly regulated by posttranslational modifications that control their function in the desmosome itself and in addition regulate a multitude of desmosome-independent functions. This review will summarize our current knowledge how signaling pathways that control epithelial shape, polarity and function regulate desmosomes and how desmosomal proteins transduce these signals to modulate cell behavior. |
| first_indexed | 2024-12-13T21:18:03Z |
| format | Article |
| id | doaj.art-c2b3edb3f30048aea275ac827ed6218a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T21:18:03Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c2b3edb3f30048aea275ac827ed6218a2022-12-21T23:31:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.745670745670Desmosomes as Signaling Hubs in the Regulation of Cell BehaviorLisa MüllerMechthild HatzfeldRené KeilDesmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to change cell behavior. Desmosome composition and size vary depending on tissue specific expression and differentiation state. Their constituent proteins are highly regulated by posttranslational modifications that control their function in the desmosome itself and in addition regulate a multitude of desmosome-independent functions. This review will summarize our current knowledge how signaling pathways that control epithelial shape, polarity and function regulate desmosomes and how desmosomal proteins transduce these signals to modulate cell behavior.https://www.frontiersin.org/articles/10.3389/fcell.2021.745670/fulldesmosomesproliferationdifferentiationbarrier functioninflammationEGFR |
| spellingShingle | Lisa Müller Mechthild Hatzfeld René Keil Desmosomes as Signaling Hubs in the Regulation of Cell Behavior Frontiers in Cell and Developmental Biology desmosomes proliferation differentiation barrier function inflammation EGFR |
| title | Desmosomes as Signaling Hubs in the Regulation of Cell Behavior |
| title_full | Desmosomes as Signaling Hubs in the Regulation of Cell Behavior |
| title_fullStr | Desmosomes as Signaling Hubs in the Regulation of Cell Behavior |
| title_full_unstemmed | Desmosomes as Signaling Hubs in the Regulation of Cell Behavior |
| title_short | Desmosomes as Signaling Hubs in the Regulation of Cell Behavior |
| title_sort | desmosomes as signaling hubs in the regulation of cell behavior |
| topic | desmosomes proliferation differentiation barrier function inflammation EGFR |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.745670/full |
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