Unraveling the Role of the Apical Papilla During Dental Root Maturation
The apical papilla is a stem cell rich tissue located at the base of the developing dental root and is responsible for the progressive elongation and maturation of the root. The multipotent stem cells of the apical papilla (SCAP) are extensively studied in cell culture since they demonstrate a high...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.665600/full |
| _version_ | 1818644142999207936 |
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| author | Ronald B. Driesen Pascal Gervois Tim Vangansewinkel Ivo Lambrichts |
| author_facet | Ronald B. Driesen Pascal Gervois Tim Vangansewinkel Ivo Lambrichts |
| author_sort | Ronald B. Driesen |
| collection | DOAJ |
| description | The apical papilla is a stem cell rich tissue located at the base of the developing dental root and is responsible for the progressive elongation and maturation of the root. The multipotent stem cells of the apical papilla (SCAP) are extensively studied in cell culture since they demonstrate a high capacity for osteogenic, adipogenic, and chondrogenic differentiation and are thus an attractive stem cell source for stem cell-based therapies. Currently, only few studies are dedicated to determining the role of the apical papilla in dental root development. In this review, we will focus on the architecture of the apical papilla and describe the specific SCAP signaling pathways involved in root maturation. Furthermore, we will explore the heterogeneity of the SCAP phenotype within the tissue and determine their micro-environmental interaction. Understanding the mechanism of postnatal dental root growth could further aid in developing novel strategies in dental root regeneration. |
| first_indexed | 2024-12-17T00:10:09Z |
| format | Article |
| id | doaj.art-c2b7952126df4a4a8b5bc8053a83367c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T00:10:09Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c2b7952126df4a4a8b5bc8053a83367c2022-12-21T22:10:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-05-01910.3389/fcell.2021.665600665600Unraveling the Role of the Apical Papilla During Dental Root MaturationRonald B. DriesenPascal GervoisTim VangansewinkelIvo LambrichtsThe apical papilla is a stem cell rich tissue located at the base of the developing dental root and is responsible for the progressive elongation and maturation of the root. The multipotent stem cells of the apical papilla (SCAP) are extensively studied in cell culture since they demonstrate a high capacity for osteogenic, adipogenic, and chondrogenic differentiation and are thus an attractive stem cell source for stem cell-based therapies. Currently, only few studies are dedicated to determining the role of the apical papilla in dental root development. In this review, we will focus on the architecture of the apical papilla and describe the specific SCAP signaling pathways involved in root maturation. Furthermore, we will explore the heterogeneity of the SCAP phenotype within the tissue and determine their micro-environmental interaction. Understanding the mechanism of postnatal dental root growth could further aid in developing novel strategies in dental root regeneration.https://www.frontiersin.org/articles/10.3389/fcell.2021.665600/fullapical papillaSCAPdentalrootdevelopment |
| spellingShingle | Ronald B. Driesen Pascal Gervois Tim Vangansewinkel Ivo Lambrichts Unraveling the Role of the Apical Papilla During Dental Root Maturation Frontiers in Cell and Developmental Biology apical papilla SCAP dental root development |
| title | Unraveling the Role of the Apical Papilla During Dental Root Maturation |
| title_full | Unraveling the Role of the Apical Papilla During Dental Root Maturation |
| title_fullStr | Unraveling the Role of the Apical Papilla During Dental Root Maturation |
| title_full_unstemmed | Unraveling the Role of the Apical Papilla During Dental Root Maturation |
| title_short | Unraveling the Role of the Apical Papilla During Dental Root Maturation |
| title_sort | unraveling the role of the apical papilla during dental root maturation |
| topic | apical papilla SCAP dental root development |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.665600/full |
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