Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer
Recently, the immune checkpoint inhibitors which target programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have made a breakthrough in the treatment of advanced non-small cell lung cancer. Researches on immune checkpoint inhibitors have been rapidly implemented in various types of lung cancer, such as sm...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2015-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2015.11.09 |
| _version_ | 1819084401489739776 |
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| author | Zhiyu HUANG Hui LI Yun FAN |
| author_facet | Zhiyu HUANG Hui LI Yun FAN |
| author_sort | Zhiyu HUANG |
| collection | DOAJ |
| description | Recently, the immune checkpoint inhibitors which target programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have made a breakthrough in the treatment of advanced non-small cell lung cancer. Researches on immune checkpoint inhibitors have been rapidly implemented in various types of lung cancer, such as small cell lung cancer and locally advanced non-small cell lung cancer. These inhibitors have been applied in combination with other treatment strategies, including chemotherapy, targeting therapy and radiotherapy. However, there are still many problems to be solved, such as searching for ideal biomarkers, exploring different combination treatment models, and identifying the potential mechanisms of primary or secondary drug resistance. Along with these problems to be successfully solved, the immune checkpoint inhibitors will have broader applications in lung cancer therapy. |
| first_indexed | 2024-12-21T20:47:53Z |
| format | Article |
| id | doaj.art-c2b9cc79ea7f4ec1a29fd882789b9ee9 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-21T20:47:53Z |
| publishDate | 2015-11-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-c2b9cc79ea7f4ec1a29fd882789b9ee92022-12-21T18:50:46ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872015-11-01181170671310.3779/j.issn.1009-3419.2015.11.09Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung CancerZhiyu HUANG0Hui LI1Yun FAN2Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, ChinaDepartment of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, ChinaDepartment of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, ChinaRecently, the immune checkpoint inhibitors which target programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have made a breakthrough in the treatment of advanced non-small cell lung cancer. Researches on immune checkpoint inhibitors have been rapidly implemented in various types of lung cancer, such as small cell lung cancer and locally advanced non-small cell lung cancer. These inhibitors have been applied in combination with other treatment strategies, including chemotherapy, targeting therapy and radiotherapy. However, there are still many problems to be solved, such as searching for ideal biomarkers, exploring different combination treatment models, and identifying the potential mechanisms of primary or secondary drug resistance. Along with these problems to be successfully solved, the immune checkpoint inhibitors will have broader applications in lung cancer therapy.http://dx.doi.org/10.3779/j.issn.1009-3419.2015.11.09CheckpointPD-1/PD-L1Monoclonal antibodyLung neoplasms |
| spellingShingle | Zhiyu HUANG Hui LI Yun FAN Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer Chinese Journal of Lung Cancer Checkpoint PD-1/PD-L1 Monoclonal antibody Lung neoplasms |
| title | Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer |
| title_full | Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer |
| title_fullStr | Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer |
| title_full_unstemmed | Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer |
| title_short | Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer |
| title_sort | clinical research progress of anti pd 1 pd l1 monoclonal antibody in the treatment of lung cancer |
| topic | Checkpoint PD-1/PD-L1 Monoclonal antibody Lung neoplasms |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2015.11.09 |
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