Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
<i>Background and Objectives:</i> Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general...
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MDPI AG
2021-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/11/1255 |
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| author | Cheol Lee SeongNam Park ByoungRyun Kim Hyeonbin Yim Myeongjong Lee Juhwan Lee Hyungtae Kim |
| author_facet | Cheol Lee SeongNam Park ByoungRyun Kim Hyeonbin Yim Myeongjong Lee Juhwan Lee Hyungtae Kim |
| author_sort | Cheol Lee |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general anesthesia. <i>Materials and Methods:</i> This retrospective study included 660 menstruating and menopausal female patients aged 19–65 years. The patients were divided into two groups according to the occurrence of inadvertent intraoperative hypothermia: non-hypothermia group (<i>N</i> = 472) and hypothermia group (<i>N</i> = 188). After propensity score matching, 312 patients (<i>N</i> = 156 in each group) were analyzed to investigate the association between intraoperative hypothermia and female reproductive hormones. As potential predictors of inadvertent hypothermia, the levels of female reproductive hormones were analyzed using binary logistic regression. <i>Results:</i> The association of estradiol (r = −0.218, <i>p</i> = 0.000) and progesterone (r = −0.235, <i>p</i> = 0.000) levels with inadvertent intraoperative hypothermia was significant but weakly negative before matching; however, it was significant and moderately negative after matching (r = −0.326, <i>p</i> = 0.000 and r = −0.485, <i>p</i> = 0.000, respectively). In a binary logistic analysis, the odds ratio for estradiol was 0.995 (<i>p</i> = 0.014, 0.993 < 95% confidence interval [CI] < 0.998) before matching and 0.993 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) after matching, and that for progesterone was 0.895 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) before matching and 0.833 (<i>p</i> = 0.014, 0.990 < 95% CI < 0.996) after matching. <i>Conclusions:</i> Estradiol and progesterone levels were associated with inadvertent intraoperative hypothermia. However, the odds ratio for female reproductive hormone levels was close to 1. Therefore, female reproductive hormones may not be a risk factor for hypothermia during gynecologic surgery under general anesthesia. However, a small sample size in this study limits the generalizability of the results. |
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| spelling | doaj.art-c2b9fb993ef64347bcc5bcf7670e7ede2023-11-23T00:18:03ZengMDPI AGMedicina1010-660X1648-91442021-11-015711125510.3390/medicina57111255Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective StudyCheol Lee0SeongNam Park1ByoungRyun Kim2Hyeonbin Yim3Myeongjong Lee4Juhwan Lee5Hyungtae Kim6Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, KoreaDepartment of Obstetrics & Gynecology, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, KoreaDepartment of Obstetrics & Gynecology, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, KoreaDepartment of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, KoreaDepartment of Anesthesiology and Pain Medicine, Konkuk University Medical School, 82 Gugwondae-ro, Chungju 27376, KoreaDepartment of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, KoreaDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea<i>Background and Objectives:</i> Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general anesthesia. <i>Materials and Methods:</i> This retrospective study included 660 menstruating and menopausal female patients aged 19–65 years. The patients were divided into two groups according to the occurrence of inadvertent intraoperative hypothermia: non-hypothermia group (<i>N</i> = 472) and hypothermia group (<i>N</i> = 188). After propensity score matching, 312 patients (<i>N</i> = 156 in each group) were analyzed to investigate the association between intraoperative hypothermia and female reproductive hormones. As potential predictors of inadvertent hypothermia, the levels of female reproductive hormones were analyzed using binary logistic regression. <i>Results:</i> The association of estradiol (r = −0.218, <i>p</i> = 0.000) and progesterone (r = −0.235, <i>p</i> = 0.000) levels with inadvertent intraoperative hypothermia was significant but weakly negative before matching; however, it was significant and moderately negative after matching (r = −0.326, <i>p</i> = 0.000 and r = −0.485, <i>p</i> = 0.000, respectively). In a binary logistic analysis, the odds ratio for estradiol was 0.995 (<i>p</i> = 0.014, 0.993 < 95% confidence interval [CI] < 0.998) before matching and 0.993 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) after matching, and that for progesterone was 0.895 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) before matching and 0.833 (<i>p</i> = 0.014, 0.990 < 95% CI < 0.996) after matching. <i>Conclusions:</i> Estradiol and progesterone levels were associated with inadvertent intraoperative hypothermia. However, the odds ratio for female reproductive hormone levels was close to 1. Therefore, female reproductive hormones may not be a risk factor for hypothermia during gynecologic surgery under general anesthesia. However, a small sample size in this study limits the generalizability of the results.https://www.mdpi.com/1648-9144/57/11/1255hypothermiagynecologic surgeryreproductive hormones |
| spellingShingle | Cheol Lee SeongNam Park ByoungRyun Kim Hyeonbin Yim Myeongjong Lee Juhwan Lee Hyungtae Kim Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study Medicina hypothermia gynecologic surgery reproductive hormones |
| title | Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study |
| title_full | Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study |
| title_fullStr | Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study |
| title_full_unstemmed | Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study |
| title_short | Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study |
| title_sort | effects of female reproductive hormone levels on inadvertent intraoperative hypothermia during laparoscopic gynecologic surgery a retrospective study |
| topic | hypothermia gynecologic surgery reproductive hormones |
| url | https://www.mdpi.com/1648-9144/57/11/1255 |
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