Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis
Introduction: The role of serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biomarker of periodontitis is well documented; however, its role in diabetic patients with periodontitis is unknown. Aim : This study was conducted to determine the presence and concentration of serum MCP-1 in diabetic p...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=4;spage=505;epage=510;aulast=Radhakrishnan |
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| author | Preethi Radhakrishnan Padma Srikanth Krishna G Seshadri Ramya Barani Maitreya Samanta |
| author_facet | Preethi Radhakrishnan Padma Srikanth Krishna G Seshadri Ramya Barani Maitreya Samanta |
| author_sort | Preethi Radhakrishnan |
| collection | DOAJ |
| description | Introduction: The role of serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biomarker of periodontitis is well documented; however, its role in diabetic patients with periodontitis is unknown. Aim : This study was conducted to determine the presence and concentration of serum MCP-1 in diabetic patients with and without periodontitis and correlate it glycemic status with periodontitis. Materials and Methods: Adult diabetic patients were enrolled and grouped into group I, II, and III based on their glycemic status and serum MCP-1 estimated by ELISA. Linear regression and correlation tests were performed using R statistical software, Medcalc software to observe correlation between the serum MCP-1 and glycated hemoglobin level among different groups. Results: Serum samples obtained from 37 patients tested positive for MCP-1. Mean serum MCP-1 concentration was highest (482.3 pg/ml) in group III, lowest (149.3 pg/ml) in group I, and intermediate 398.8 pg/ml in group II. Correlation and regression analysis was done between HbA1c and serum MCP-1. A significant positive correlation (P < 0.001) was observed. Serum MCP-1 increased by 37.278 pg/ml for every 1% rise in HbA1c, and the levels were raised in group II and group III than in group I irrespective of their glycemic status. With an HbA1c range of 6.5-6.9% (group II), the serum MCP-1 values cluster around 380-410 pg/ml. Elevated levels of serum MCP-1 (>500 pg/ml) in three subjects corresponded to HbA1c values more than 12.2% (group III). Conclusion: To our knowledge, this is the first study to document serum MCP-1 levels in diabetic patients with periodontitis. Glycemic status influences serum MCP-1, and lack of glycemic control contributes to increased serum MCP-1 levels. Serum MCP-1 may thus serve as a biomarker of inflammation and disease progression in diabetes with periodontitis. |
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| format | Article |
| id | doaj.art-c2bcfe30b019489d907c690604e7f6e6 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-13T01:35:42Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-c2bcfe30b019489d907c690604e7f6e62022-12-22T03:08:24ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002014-01-0118450551010.4103/2230-8210.137498Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitisPreethi RadhakrishnanPadma SrikanthKrishna G SeshadriRamya BaraniMaitreya SamantaIntroduction: The role of serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biomarker of periodontitis is well documented; however, its role in diabetic patients with periodontitis is unknown. Aim : This study was conducted to determine the presence and concentration of serum MCP-1 in diabetic patients with and without periodontitis and correlate it glycemic status with periodontitis. Materials and Methods: Adult diabetic patients were enrolled and grouped into group I, II, and III based on their glycemic status and serum MCP-1 estimated by ELISA. Linear regression and correlation tests were performed using R statistical software, Medcalc software to observe correlation between the serum MCP-1 and glycated hemoglobin level among different groups. Results: Serum samples obtained from 37 patients tested positive for MCP-1. Mean serum MCP-1 concentration was highest (482.3 pg/ml) in group III, lowest (149.3 pg/ml) in group I, and intermediate 398.8 pg/ml in group II. Correlation and regression analysis was done between HbA1c and serum MCP-1. A significant positive correlation (P < 0.001) was observed. Serum MCP-1 increased by 37.278 pg/ml for every 1% rise in HbA1c, and the levels were raised in group II and group III than in group I irrespective of their glycemic status. With an HbA1c range of 6.5-6.9% (group II), the serum MCP-1 values cluster around 380-410 pg/ml. Elevated levels of serum MCP-1 (>500 pg/ml) in three subjects corresponded to HbA1c values more than 12.2% (group III). Conclusion: To our knowledge, this is the first study to document serum MCP-1 levels in diabetic patients with periodontitis. Glycemic status influences serum MCP-1, and lack of glycemic control contributes to increased serum MCP-1 levels. Serum MCP-1 may thus serve as a biomarker of inflammation and disease progression in diabetes with periodontitis.http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=4;spage=505;epage=510;aulast=RadhakrishnanGlycemic controlperiodontitisserum Monocyte Chemoattractant Protein-1 |
| spellingShingle | Preethi Radhakrishnan Padma Srikanth Krishna G Seshadri Ramya Barani Maitreya Samanta Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis Indian Journal of Endocrinology and Metabolism Glycemic control periodontitis serum Monocyte Chemoattractant Protein-1 |
| title | Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis |
| title_full | Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis |
| title_fullStr | Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis |
| title_full_unstemmed | Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis |
| title_short | Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis |
| title_sort | serum monocyte chemoattractant protein 1 is a biomarker in patients with diabetes and periodontitis |
| topic | Glycemic control periodontitis serum Monocyte Chemoattractant Protein-1 |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=4;spage=505;epage=510;aulast=Radhakrishnan |
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