Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings

Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings

Objective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks’) and 72 matched healthy controls were included. SVRI was calculated f...

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Bibliographic Details
Main Authors: Miha Lucovnik, Helmut Karl Lackner, Ilona Papousek, Karin Schmid-Zalaudek, Guenter Schulter, Andreas Roessler, Manfred Georg Moertl
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:Hypertension in Pregnancy
Subjects:
adma
case-control methodology
nitric oxide synthesis
preeclampsia
sdma
Online Access:http://dx.doi.org/10.1080/10641955.2017.1364381
Description
Summary:Objective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks’) and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay. Results: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls. SVRI was correlated with ADMA and SDMA, respectively. Conclusions: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors.
ISSN:1064-1955
1525-6065

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