Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings
Objective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks’) and 72 matched healthy controls were included. SVRI was calculated f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-07-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2017.1364381 |
| _version_ | 1797681605921210368 |
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| author | Miha Lucovnik Helmut Karl Lackner Ilona Papousek Karin Schmid-Zalaudek Guenter Schulter Andreas Roessler Manfred Georg Moertl |
| author_facet | Miha Lucovnik Helmut Karl Lackner Ilona Papousek Karin Schmid-Zalaudek Guenter Schulter Andreas Roessler Manfred Georg Moertl |
| author_sort | Miha Lucovnik |
| collection | DOAJ |
| description | Objective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks’) and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay. Results: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls. SVRI was correlated with ADMA and SDMA, respectively. Conclusions: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors. |
| first_indexed | 2024-03-11T23:47:22Z |
| format | Article |
| id | doaj.art-c2bd37096a3f4f6aa2c26ee5e381f696 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:47:22Z |
| publishDate | 2017-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-c2bd37096a3f4f6aa2c26ee5e381f6962023-09-19T09:24:42ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652017-07-0136327628110.1080/10641955.2017.13643811364381Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findingsMiha Lucovnik0Helmut Karl Lackner1Ilona Papousek2Karin Schmid-Zalaudek3Guenter Schulter4Andreas Roessler5Manfred Georg Moertl6University Medical Centre LjubljanaMedical University of GrazUniversity of GrazMedical University of GrazUniversity of GrazMedical University of GrazClinical CenterObjective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks’) and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay. Results: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls. SVRI was correlated with ADMA and SDMA, respectively. Conclusions: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors.http://dx.doi.org/10.1080/10641955.2017.1364381admacase-control methodologynitric oxide synthesispreeclampsiasdma |
| spellingShingle | Miha Lucovnik Helmut Karl Lackner Ilona Papousek Karin Schmid-Zalaudek Guenter Schulter Andreas Roessler Manfred Georg Moertl Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings Hypertension in Pregnancy adma case-control methodology nitric oxide synthesis preeclampsia sdma |
| title | Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings |
| title_full | Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings |
| title_fullStr | Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings |
| title_full_unstemmed | Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings |
| title_short | Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings |
| title_sort | systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early compared to late onset preeclampsia preliminary findings |
| topic | adma case-control methodology nitric oxide synthesis preeclampsia sdma |
| url | http://dx.doi.org/10.1080/10641955.2017.1364381 |
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