Phage Therapy with a Focus on the Human Microbiota
Bacteriophages are viruses that infect bacteria. After their discovery in the early 1900s, bacteriophages were a primary cure against infectious disease for almost 25 years, before being completely overshadowed by antibiotics. With the rise of antibiotic resistance, bacteriophages are being explored...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/3/131 |
| _version_ | 1818337445128699904 |
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| author | Sharita Divya Ganeshan Zeinab Hosseinidoust |
| author_facet | Sharita Divya Ganeshan Zeinab Hosseinidoust |
| author_sort | Sharita Divya Ganeshan |
| collection | DOAJ |
| description | Bacteriophages are viruses that infect bacteria. After their discovery in the early 1900s, bacteriophages were a primary cure against infectious disease for almost 25 years, before being completely overshadowed by antibiotics. With the rise of antibiotic resistance, bacteriophages are being explored again for their antibacterial activity. One of the critical apprehensions regarding bacteriophage therapy, however, is the possibility of genome evolution, development of phage resistance, and subsequent perturbations to our microbiota. Through this review, we set out to explore the principles supporting the use of bacteriophages as a therapeutic agent, discuss the human gut microbiome in relation to the utilization of phage therapy, and the co-evolutionary arms race between host bacteria and phage in the context of the human microbiota. |
| first_indexed | 2024-12-13T14:55:19Z |
| format | Article |
| id | doaj.art-c2bd7177d7874286aad7cfb7838f726f |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-13T14:55:19Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-c2bd7177d7874286aad7cfb7838f726f2022-12-21T23:41:15ZengMDPI AGAntibiotics2079-63822019-08-018313110.3390/antibiotics8030131antibiotics8030131Phage Therapy with a Focus on the Human MicrobiotaSharita Divya Ganeshan0Zeinab Hosseinidoust1School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, CanadaBacteriophages are viruses that infect bacteria. After their discovery in the early 1900s, bacteriophages were a primary cure against infectious disease for almost 25 years, before being completely overshadowed by antibiotics. With the rise of antibiotic resistance, bacteriophages are being explored again for their antibacterial activity. One of the critical apprehensions regarding bacteriophage therapy, however, is the possibility of genome evolution, development of phage resistance, and subsequent perturbations to our microbiota. Through this review, we set out to explore the principles supporting the use of bacteriophages as a therapeutic agent, discuss the human gut microbiome in relation to the utilization of phage therapy, and the co-evolutionary arms race between host bacteria and phage in the context of the human microbiota.https://www.mdpi.com/2079-6382/8/3/131microbiome therapyphage therapyevolutionantibiotic resistance |
| spellingShingle | Sharita Divya Ganeshan Zeinab Hosseinidoust Phage Therapy with a Focus on the Human Microbiota Antibiotics microbiome therapy phage therapy evolution antibiotic resistance |
| title | Phage Therapy with a Focus on the Human Microbiota |
| title_full | Phage Therapy with a Focus on the Human Microbiota |
| title_fullStr | Phage Therapy with a Focus on the Human Microbiota |
| title_full_unstemmed | Phage Therapy with a Focus on the Human Microbiota |
| title_short | Phage Therapy with a Focus on the Human Microbiota |
| title_sort | phage therapy with a focus on the human microbiota |
| topic | microbiome therapy phage therapy evolution antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/8/3/131 |
| work_keys_str_mv | AT sharitadivyaganeshan phagetherapywithafocusonthehumanmicrobiota AT zeinabhosseinidoust phagetherapywithafocusonthehumanmicrobiota |