Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Abstract Background The bone marrow is the place of hematopoiesis with a microenvironment that supports lifelong maintenance of stem cells and high proliferation. It is not surprising that this environment is also favourable for malignant cells emerging in the bone marrow or metastasizing to it. Whi...

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Bibliographic Details
Main Authors: Lorenz Nierves, Jian Guo, Siyuan Chen, Janice Tsui, Anuli C. Uzozie, Jonathan W. Bush, Tao Huan, Philipp F. Lange
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Experimental Hematology & Oncology
Subjects:
Acute lymphoblastic leukemia
Microenviroment
Bone marrow interstitial fluid
Peripheral blood plasma
Online Access:https://doi.org/10.1186/s40164-022-00310-0

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