A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets
Ankylosing spondylitis (AS) is a chronic immune-mediated type of inflammatory arthritis characterized by inflammation, bone erosion, and stiffness of the spine and sacroiliac joints. Despite great efforts put into the investigation of the disease, the pathogenesis of AS remains unclear, posing chall...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1362476/full |
| _version_ | 1797246750575034368 |
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| author | Hanji Wang Chengxian Yang Ge Li Boning Wang Longtao Qi Yu Wang |
| author_facet | Hanji Wang Chengxian Yang Ge Li Boning Wang Longtao Qi Yu Wang |
| author_sort | Hanji Wang |
| collection | DOAJ |
| description | Ankylosing spondylitis (AS) is a chronic immune-mediated type of inflammatory arthritis characterized by inflammation, bone erosion, and stiffness of the spine and sacroiliac joints. Despite great efforts put into the investigation of the disease, the pathogenesis of AS remains unclear, posing challenges in identifying ideal targets for diagnosis and treatment. To enhance our understanding of AS, an increasing number of studies have been conducted. Some of these studies reveal that long non-coding RNAs (lncRNAs) play crucial roles in the etiology of AS. Some certain lncRNAs influence the development of AS by regulating inflammatory responses, autophagy, apoptosis, and adipogenesis, as well as the proliferation and differentiation of cells. Additionally, some lncRNAs demonstrate potential as biomarkers, aiding in monitoring disease progression and predicting prognosis. In this review, we summarize recent studies concerning lncRNAs in AS to elucidate the underlying mechanisms in which lncRNAs are involved and their potential values as biomarkers for disease assessment and druggable targets for therapy. |
| first_indexed | 2024-04-24T19:47:46Z |
| format | Article |
| id | doaj.art-c2bebcf935a4484f9262f7b0b798ab87 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-24T19:47:46Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c2bebcf935a4484f9262f7b0b798ab872024-03-25T04:29:49ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-03-011210.3389/fcell.2024.13624761362476A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targetsHanji Wang0Chengxian Yang1Ge Li2Boning Wang3Longtao Qi4Yu Wang5Department of Orthopaedics, Peking University First Hospital, Beijing, ChinaDepartment of Orthopaedics, Peking University First Hospital, Beijing, ChinaDepartment of Endocrinology, Peking University First Hospital, Beijing, ChinaDepartment of Orthopaedics, Peking University First Hospital, Beijing, ChinaDepartment of Orthopaedics, Peking University First Hospital, Beijing, ChinaDepartment of Orthopaedics, Peking University First Hospital, Beijing, ChinaAnkylosing spondylitis (AS) is a chronic immune-mediated type of inflammatory arthritis characterized by inflammation, bone erosion, and stiffness of the spine and sacroiliac joints. Despite great efforts put into the investigation of the disease, the pathogenesis of AS remains unclear, posing challenges in identifying ideal targets for diagnosis and treatment. To enhance our understanding of AS, an increasing number of studies have been conducted. Some of these studies reveal that long non-coding RNAs (lncRNAs) play crucial roles in the etiology of AS. Some certain lncRNAs influence the development of AS by regulating inflammatory responses, autophagy, apoptosis, and adipogenesis, as well as the proliferation and differentiation of cells. Additionally, some lncRNAs demonstrate potential as biomarkers, aiding in monitoring disease progression and predicting prognosis. In this review, we summarize recent studies concerning lncRNAs in AS to elucidate the underlying mechanisms in which lncRNAs are involved and their potential values as biomarkers for disease assessment and druggable targets for therapy.https://www.frontiersin.org/articles/10.3389/fcell.2024.1362476/fullankylosing spondylitislong non-coding RNApathogenesisbiomarkertherapy |
| spellingShingle | Hanji Wang Chengxian Yang Ge Li Boning Wang Longtao Qi Yu Wang A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets Frontiers in Cell and Developmental Biology ankylosing spondylitis long non-coding RNA pathogenesis biomarker therapy |
| title | A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets |
| title_full | A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets |
| title_fullStr | A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets |
| title_full_unstemmed | A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets |
| title_short | A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets |
| title_sort | review of long non coding rnas in ankylosing spondylitis pathogenesis clinical assessment and therapeutic targets |
| topic | ankylosing spondylitis long non-coding RNA pathogenesis biomarker therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1362476/full |
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