Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers?
Non-celiac wheat sensitivity (NCWS) is a clinical entity induced by the ingestion of gluten that leads to intestinal and/or extraintestinal symptoms, and is diagnosed when celiac disease and wheat allergy have been ruled out. In addition to gluten, other grains’ components, including amylase trypsin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/15/2389 |
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| author | Vera Rotondi Aufiero Anna Sapone Giuseppe Mazzarella |
| author_facet | Vera Rotondi Aufiero Anna Sapone Giuseppe Mazzarella |
| author_sort | Vera Rotondi Aufiero |
| collection | DOAJ |
| description | Non-celiac wheat sensitivity (NCWS) is a clinical entity induced by the ingestion of gluten that leads to intestinal and/or extraintestinal symptoms, and is diagnosed when celiac disease and wheat allergy have been ruled out. In addition to gluten, other grains’ components, including amylase trypsin inhibitors (ATIs) and fermentable short-chain carbohydrates (FODMAPs), may trigger symptoms in NCWS subjects. Several studies suggest that, compared with tetraploid and hexaploid modern wheats, ancient diploid wheats species could possess a lower immunogenicity for subjects suffering from NCWS. This review aims to discuss available evidence related to the immunological features of diploid wheats compared to common wheats, and at outlining new dietary opportunities for NCWS subjects. |
| first_indexed | 2024-03-09T05:31:41Z |
| format | Article |
| id | doaj.art-c2bec08ac507486a95a661bbc4a26ed8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:31:41Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c2bec08ac507486a95a661bbc4a26ed82023-12-03T12:32:29ZengMDPI AGCells2073-44092022-08-011115238910.3390/cells11152389Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers?Vera Rotondi Aufiero0Anna Sapone1Giuseppe Mazzarella2Institute of Food Sciences, CNR, 83100 Avellino, ItalyCenter for Celiac Research and Treatment, Massachusetts General Hospital, Boston, MA 02114, USAInstitute of Food Sciences, CNR, 83100 Avellino, ItalyNon-celiac wheat sensitivity (NCWS) is a clinical entity induced by the ingestion of gluten that leads to intestinal and/or extraintestinal symptoms, and is diagnosed when celiac disease and wheat allergy have been ruled out. In addition to gluten, other grains’ components, including amylase trypsin inhibitors (ATIs) and fermentable short-chain carbohydrates (FODMAPs), may trigger symptoms in NCWS subjects. Several studies suggest that, compared with tetraploid and hexaploid modern wheats, ancient diploid wheats species could possess a lower immunogenicity for subjects suffering from NCWS. This review aims to discuss available evidence related to the immunological features of diploid wheats compared to common wheats, and at outlining new dietary opportunities for NCWS subjects.https://www.mdpi.com/2073-4409/11/15/2389non celiac wheat sensitivitydiploid wheatcommon wheatamylase trypsin inhibitorFODMAP |
| spellingShingle | Vera Rotondi Aufiero Anna Sapone Giuseppe Mazzarella Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers? Cells non celiac wheat sensitivity diploid wheat common wheat amylase trypsin inhibitor FODMAP |
| title | Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers? |
| title_full | Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers? |
| title_fullStr | Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers? |
| title_full_unstemmed | Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers? |
| title_short | Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers? |
| title_sort | diploid wheats are they less immunogenic for non celiac wheat sensitive consumers |
| topic | non celiac wheat sensitivity diploid wheat common wheat amylase trypsin inhibitor FODMAP |
| url | https://www.mdpi.com/2073-4409/11/15/2389 |
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