Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru
We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2021-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/7/20-3900_article |
| _version_ | 1828951004248276992 |
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| author | Maria L. Morales Melinda B. Tanabe A. Clinton White Martha Lopez Ruben Bascope Miguel M. Cabada |
| author_facet | Maria L. Morales Melinda B. Tanabe A. Clinton White Martha Lopez Ruben Bascope Miguel M. Cabada |
| author_sort | Maria L. Morales |
| collection | DOAJ |
| description | We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1–4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean ± SD age was 10.4 ± 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed. |
| first_indexed | 2024-12-14T06:31:44Z |
| format | Article |
| id | doaj.art-c2befb7139c6493b875973951e187f2e |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T06:31:44Z |
| publishDate | 2021-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-c2befb7139c6493b875973951e187f2e2022-12-21T23:13:30ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-07-012771850185710.3201/eid2707.203900Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, PeruMaria L. MoralesMelinda B. TanabeA. Clinton WhiteMartha LopezRuben BascopeMiguel M. CabadaWe conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1–4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean ± SD age was 10.4 ± 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed.https://wwwnc.cdc.gov/eid/article/27/7/20-3900_articletriclabendazoletreatment failurefascioliasisFasciola hepaticaliver fluketrematode |
| spellingShingle | Maria L. Morales Melinda B. Tanabe A. Clinton White Martha Lopez Ruben Bascope Miguel M. Cabada Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru Emerging Infectious Diseases triclabendazole treatment failure fascioliasis Fasciola hepatica liver fluke trematode |
| title | Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru |
| title_full | Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru |
| title_fullStr | Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru |
| title_full_unstemmed | Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru |
| title_short | Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru |
| title_sort | triclabendazole treatment failure for fasciola hepatica infection among preschool and school age children cusco peru |
| topic | triclabendazole treatment failure fascioliasis Fasciola hepatica liver fluke trematode |
| url | https://wwwnc.cdc.gov/eid/article/27/7/20-3900_article |
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