Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Abstract Background Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fiber cross-sectional area and protein content due, in part, to the proteol...

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Bibliographic Details
Main Authors: Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C. LaCasse, Robert G. Korneluk
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Skeletal Muscle
Subjects:
cIAP1
NF-κB
Muscle atrophy
MuRF1
Atrogin-1
Denervation
Online Access:http://link.springer.com/article/10.1186/s13395-019-0201-6

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