Catastrophic antiphospholipid syndrome. Pathogenesis issues

Сatastrophic antiphospholipid syndrome (CAPS) is an uncommon, often fatal, variant of the antiphospholipid syndrome that results in a widespread coagulopathy and high titres os antiphospholipid antibodies and affects predominantly small vessels supplying organs with the development of multiorgan fai...

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Main Authors: V. O. Bitsadze, D. K. Khizroeva, L. E. Idrisova, R. R. Abramyan, M. D. Andreeva, A. D. Makatsariya
Format: Article
Language:Russian
Published: IRBIS LLC 2016-06-01
Series:Акушерство, гинекология и репродукция
Subjects:
Online Access:https://www.gynecology.su/jour/article/view/156
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author V. O. Bitsadze
D. K. Khizroeva
L. E. Idrisova
R. R. Abramyan
M. D. Andreeva
A. D. Makatsariya
author_facet V. O. Bitsadze
D. K. Khizroeva
L. E. Idrisova
R. R. Abramyan
M. D. Andreeva
A. D. Makatsariya
author_sort V. O. Bitsadze
collection DOAJ
description Сatastrophic antiphospholipid syndrome (CAPS) is an uncommon, often fatal, variant of the antiphospholipid syndrome that results in a widespread coagulopathy and high titres os antiphospholipid antibodies and affects predominantly small vessels supplying organs with the development of multiorgan failure. International approaches on terminology, risk factors, pathogenesis, criteria of diagnostics, clinical symptoms and management of patients with CAPS are reviewed. Own clinical experience of management 17 patients with CAPS development also presented. CAPS is life-threatening condition but optimal treatment for CAPS is not developed yet. CAPS presents a multidisciplinary problem.
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spelling doaj.art-c2c2a691338745b6b9ccdf48b644791a2023-03-13T07:09:46ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-06-0192325310.17749/2070-4968.2015.9.2.032-053154Catastrophic antiphospholipid syndrome. Pathogenesis issuesV. O. Bitsadze0D. K. Khizroeva1L. E. Idrisova2R. R. Abramyan3M. D. Andreeva4A. D. Makatsariya5First Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationKuban State Medical University of the Russian Health Ministry, KrasnodarFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationСatastrophic antiphospholipid syndrome (CAPS) is an uncommon, often fatal, variant of the antiphospholipid syndrome that results in a widespread coagulopathy and high titres os antiphospholipid antibodies and affects predominantly small vessels supplying organs with the development of multiorgan failure. International approaches on terminology, risk factors, pathogenesis, criteria of diagnostics, clinical symptoms and management of patients with CAPS are reviewed. Own clinical experience of management 17 patients with CAPS development also presented. CAPS is life-threatening condition but optimal treatment for CAPS is not developed yet. CAPS presents a multidisciplinary problem.https://www.gynecology.su/jour/article/view/156antiphospholipid syndromerare diseasethrombotic stormcatastrophic aps
spellingShingle V. O. Bitsadze
D. K. Khizroeva
L. E. Idrisova
R. R. Abramyan
M. D. Andreeva
A. D. Makatsariya
Catastrophic antiphospholipid syndrome. Pathogenesis issues
Акушерство, гинекология и репродукция
antiphospholipid syndrome
rare disease
thrombotic storm
catastrophic aps
title Catastrophic antiphospholipid syndrome. Pathogenesis issues
title_full Catastrophic antiphospholipid syndrome. Pathogenesis issues
title_fullStr Catastrophic antiphospholipid syndrome. Pathogenesis issues
title_full_unstemmed Catastrophic antiphospholipid syndrome. Pathogenesis issues
title_short Catastrophic antiphospholipid syndrome. Pathogenesis issues
title_sort catastrophic antiphospholipid syndrome pathogenesis issues
topic antiphospholipid syndrome
rare disease
thrombotic storm
catastrophic aps
url https://www.gynecology.su/jour/article/view/156
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AT dkkhizroeva catastrophicantiphospholipidsyndromepathogenesisissues
AT leidrisova catastrophicantiphospholipidsyndromepathogenesisissues
AT rrabramyan catastrophicantiphospholipidsyndromepathogenesisissues
AT mdandreeva catastrophicantiphospholipidsyndromepathogenesisissues
AT admakatsariya catastrophicantiphospholipidsyndromepathogenesisissues