Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene

Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene

Abstract Background Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem cells (CSC) which confer resistance against standard chemo- and radiother...

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Main Authors: Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Armando Felsani, Giuseppe Tringali, Ingrid Cifola, Giacomo Pozzoli, Carlo Cenciarelli
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cancer Cell International
Subjects:
GBM
Exome
Sequencing
Cancer stem cells
Genetic variants
Online Access:https://doi.org/10.1186/s12935-021-02419-4

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