Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα–NF-κB p65 Complex

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα–NF-κB p65 Complex

Osteoporosis affects around 200 million people globally, with menopausal women accounting for the bulk of cases. In the occurrence and development of osteoporosis, a key role is played by osteoclasts. Excessive osteoclast-mediated bone resorption activity reduces bone mass and increases bone fragili...

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Bibliographic Details
Main Authors: Junchun Chen, Dezhi Song, Yang Xu, Liwei Wu, Lili Tang, YuanGang Su, Xiaoxiao Xie, Jinmin Zhao, Jiake Xu, Qian Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
eltanexor (KPT-8602)
selinexor (KPT-330)
NF-κB
XPO1
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.896108/full

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