Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine
The improvement of electrochemical detection of meloxicam is presented bymodification of a glassy carbon electrode with anionic layer of cysteic acid providingelectrostatic accumulation of the analyte onto the electrode surface. The modificationformed by electrochemical oxidation of L-cysteine was p...
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MDPI AG
2006-09-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/6/9/1139 |
| _version_ | 1797481104775577600 |
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| author | Cheng Yin Wang Zhi Xian Wang Jun Guan Xiao Ya Hu |
| author_facet | Cheng Yin Wang Zhi Xian Wang Jun Guan Xiao Ya Hu |
| author_sort | Cheng Yin Wang |
| collection | DOAJ |
| description | The improvement of electrochemical detection of meloxicam is presented bymodification of a glassy carbon electrode with anionic layer of cysteic acid providingelectrostatic accumulation of the analyte onto the electrode surface. The modificationformed by electrochemical oxidation of L-cysteine was performed by cycling potential incysteine solution. The anodic peak current obtained at 1.088 V (vs. Ag/AgCl) byvoltammetry was linearly dependent on the meloxicam concentration in the range of 4.3 ×10<sup>-8</sup> ~ 8.5 × 10<sup>-6 </sup>M in the B-R buffer solution (0.04 M, pH 1.86) with a correlationcoefficient of 0.999. The detection limit (S/N = 3) is 1.5 × 10<sup>-9</sup> M. The low-cost modifiedelectrode shows good sensitivity, selectivity and stability and has been applied to thedetermination of meloxicam in pharmaceutical formulation and spiked serum withsatisfactory results. The electrochemical reaction mechanism of meloxicam was discussed. |
| first_indexed | 2024-03-09T22:09:45Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T22:09:45Z |
| publishDate | 2006-09-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-c2c58999aa63473bb6271bae0545aa3e2023-11-23T19:34:18ZengMDPI AGSensors1424-82202006-09-01691139115210.3390/s6091139Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteineCheng Yin Wang0Zhi Xian Wang1Jun Guan2Xiao Ya Hu3Department of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, ChinaDepartment of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, ChinaSubei Hospital, Yangzhou 225002, ChinaDepartment of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, ChinaThe improvement of electrochemical detection of meloxicam is presented bymodification of a glassy carbon electrode with anionic layer of cysteic acid providingelectrostatic accumulation of the analyte onto the electrode surface. The modificationformed by electrochemical oxidation of L-cysteine was performed by cycling potential incysteine solution. The anodic peak current obtained at 1.088 V (vs. Ag/AgCl) byvoltammetry was linearly dependent on the meloxicam concentration in the range of 4.3 ×10<sup>-8</sup> ~ 8.5 × 10<sup>-6 </sup>M in the B-R buffer solution (0.04 M, pH 1.86) with a correlationcoefficient of 0.999. The detection limit (S/N = 3) is 1.5 × 10<sup>-9</sup> M. The low-cost modifiedelectrode shows good sensitivity, selectivity and stability and has been applied to thedetermination of meloxicam in pharmaceutical formulation and spiked serum withsatisfactory results. The electrochemical reaction mechanism of meloxicam was discussed.https://www.mdpi.com/1424-8220/6/9/1139cysteic acidL-cysteinemeloxicamvoltammetryhuman serum |
| spellingShingle | Cheng Yin Wang Zhi Xian Wang Jun Guan Xiao Ya Hu Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine Sensors cysteic acid L-cysteine meloxicam voltammetry human serum |
| title | Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine |
| title_full | Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine |
| title_fullStr | Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine |
| title_full_unstemmed | Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine |
| title_short | Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine |
| title_sort | voltammetric determination of meloxicam in pharmaceutical formulation and human serum at glassy carbon electrode modified by cysteic acid formed by electrochemical oxidation of l cysteine |
| topic | cysteic acid L-cysteine meloxicam voltammetry human serum |
| url | https://www.mdpi.com/1424-8220/6/9/1139 |
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