Effects of Essential Amino Acid Deficiency on General Control Nonderepressible 2/Eukaryotic Initiation Factor 2 Signaling and Proteomic Changes in Primary Bovine Mammary Epithelial Cells

Effects of Essential Amino Acid Deficiency on General Control Nonderepressible 2/Eukaryotic Initiation Factor 2 Signaling and Proteomic Changes in Primary Bovine Mammary Epithelial Cells

We hypothesized that the general control nonderepressible 2 (GCN2)/eukaryotic initiation factor 2 (eIF2) signaling pathway and intracellular protein synthesis (PS) are regulated to maintain milk PS in primary bovine mammary epithelial cells (MECs) under essential amino acid (EAA) starvation conditio...

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Bibliographic Details
Main Authors: Zulma Tatiana Ruiz-Cortés, Peter Yoder, Mark D. Hanigan
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Current Issues in Molecular Biology
Subjects:
caseins
eukaryotic initiation factor 2
protein biosynthesis
epithelial cells
homeostasis
Online Access:https://www.mdpi.com/1467-3045/44/3/71

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