Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling
Acute myeloid leukemia (AML) is a life-threatening aggressive malignancy of the bone marrow and has posed a great challenge to the clinic, due to a lack of fully understanding of the molecular mechanism. Histone deacetylase 1 (HDAC1) has been reported to be a therapeutic target for treating AML. Nar...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023030335 |
| _version_ | 1797815663930114048 |
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| author | Chao Wen Xiaoliang Lu Yingyin Sun Qi Li Jing Liao Lin Li |
| author_facet | Chao Wen Xiaoliang Lu Yingyin Sun Qi Li Jing Liao Lin Li |
| author_sort | Chao Wen |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is a life-threatening aggressive malignancy of the bone marrow and has posed a great challenge to the clinic, due to a lack of fully understanding of the molecular mechanism. Histone deacetylase 1 (HDAC1) has been reported to be a therapeutic target for treating AML. Naringenin (Nar) may act as an anti-leukemic agent and suppress the expression of HDACs. However, the potential underlying mechanism of Nar in suppressing the activity of HDAC1 remains unclear. Here, we found that Nar induced the apoptosis, decreased the expression of lncRNA XIST and HDAC1, and increased the expression of microRNA-34a in HL60 cells. Sh-XIST transfection could induce cell apoptosis. On the contrary, the forced expression of XIST might reverse the biological actions of Nar. XIST could sponge miR-34a, which targeted to degrade HDAC1. The forced expression of HDAC1 could effectively reverse the effects of Nar. Thus, Nar can induce cell apoptosis by mediating the expression of lncRNA XIST/miR-34a/HDAC1 signaling in HL60 cells. |
| first_indexed | 2024-03-13T08:26:08Z |
| format | Article |
| id | doaj.art-c2c94edddc694f4cb01a74c2b96f12d5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:26:08Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c2c94edddc694f4cb01a74c2b96f12d52023-05-31T04:45:40ZengElsevierHeliyon2405-84402023-05-0195e15826Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signalingChao Wen0Xiaoliang Lu1Yingyin Sun2Qi Li3Jing Liao4Lin Li5School of Nursing, Gannan Medical University, Ganzhou, 341000, ChinaDepartment of General Surgery, Ningdu County People's Hospital, Ganzhou, 341000, ChinaGannan Health Vocational College, Ganzhou, 341000, ChinaDepartment of Basic Medicine, Chuxiong Medical and Pharmaceutical College, Chuxiong, 675005, ChinaSchool of Nursing, Gannan Medical University, Ganzhou, 341000, ChinaDepartment of Hematology, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China; Corresponding author.Acute myeloid leukemia (AML) is a life-threatening aggressive malignancy of the bone marrow and has posed a great challenge to the clinic, due to a lack of fully understanding of the molecular mechanism. Histone deacetylase 1 (HDAC1) has been reported to be a therapeutic target for treating AML. Naringenin (Nar) may act as an anti-leukemic agent and suppress the expression of HDACs. However, the potential underlying mechanism of Nar in suppressing the activity of HDAC1 remains unclear. Here, we found that Nar induced the apoptosis, decreased the expression of lncRNA XIST and HDAC1, and increased the expression of microRNA-34a in HL60 cells. Sh-XIST transfection could induce cell apoptosis. On the contrary, the forced expression of XIST might reverse the biological actions of Nar. XIST could sponge miR-34a, which targeted to degrade HDAC1. The forced expression of HDAC1 could effectively reverse the effects of Nar. Thus, Nar can induce cell apoptosis by mediating the expression of lncRNA XIST/miR-34a/HDAC1 signaling in HL60 cells.http://www.sciencedirect.com/science/article/pii/S2405844023030335NaringeninHL60 cellslncRNA XISTmiR-34aHDAC1 |
| spellingShingle | Chao Wen Xiaoliang Lu Yingyin Sun Qi Li Jing Liao Lin Li Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling Heliyon Naringenin HL60 cells lncRNA XIST miR-34a HDAC1 |
| title | Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling |
| title_full | Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling |
| title_fullStr | Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling |
| title_full_unstemmed | Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling |
| title_short | Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling |
| title_sort | naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncrna xist mir 34a hdac1 signaling |
| topic | Naringenin HL60 cells lncRNA XIST miR-34a HDAC1 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023030335 |
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