Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient
Hepatitis E virus (HEV) is one of the most important public health issues around the world, and chronic HEV infection has been reported in immunosuppressed individuals. This study reported a male case, with very severe aplastic anemia (AA), who developed chronic hepatitis E after hematopoietic stem...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.954697/full |
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| author | Zihao Chen Junfeng Wei Li Jiang Dong Ying Dong Ying Weikun Tian Weikun Tian Mengyang Zhang Guiping Wen Siling Wang Chang Liu Yingbin Wang Yingbin Wang Ting Wu Ting Wu Zimin Tang Zimin Tang Zizheng Zheng Zizheng Zheng Li Yan Ningshao Xia Ningshao Xia Ningshao Xia Ningshao Xia |
| author_facet | Zihao Chen Junfeng Wei Li Jiang Dong Ying Dong Ying Weikun Tian Weikun Tian Mengyang Zhang Guiping Wen Siling Wang Chang Liu Yingbin Wang Yingbin Wang Ting Wu Ting Wu Zimin Tang Zimin Tang Zizheng Zheng Zizheng Zheng Li Yan Ningshao Xia Ningshao Xia Ningshao Xia Ningshao Xia |
| author_sort | Zihao Chen |
| collection | DOAJ |
| description | Hepatitis E virus (HEV) is one of the most important public health issues around the world, and chronic HEV infection has been reported in immunosuppressed individuals. This study reported a male case, with very severe aplastic anemia (AA), who developed chronic hepatitis E after hematopoietic stem cell transplantation (HSCT). Abnormal alanine aminotransferase (ALT) appeared after HSCT and persisted for twenty-nine months. The case was seropositive for anti-HEV IgG and IgM after HSCT. Twenty-two months after HSCT, HEV RNA and antigen (Ag) testing were positive and persisted for five and seven months, respectively. Positive stains of HEV Ag were present in a liver biopsy sample. HEV Ag was present in bone marrow. The individual rapidly developed liver cirrhosis and was rescued by a regimen of oral ribavirin. These factors suggested there is a risk of HEV infection in HSCT recipients. |
| first_indexed | 2024-04-12T10:09:13Z |
| format | Article |
| id | doaj.art-c2c984d180e0479085b7b161f1b18ba6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T10:09:13Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c2c984d180e0479085b7b161f1b18ba62022-12-22T03:37:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.954697954697Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipientZihao Chen0Junfeng Wei1Li Jiang2Dong Ying3Dong Ying4Weikun Tian5Weikun Tian6Mengyang Zhang7Guiping Wen8Siling Wang9Chang Liu10Yingbin Wang11Yingbin Wang12Ting Wu13Ting Wu14Zimin Tang15Zimin Tang16Zizheng Zheng17Zizheng Zheng18Li Yan19Ningshao Xia20Ningshao Xia21Ningshao Xia22Ningshao Xia23State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaDepartment of Infectious Diseases, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Hematology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Life Sciences, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Life Sciences, Xiamen University, Xiamen, ChinaDepartment of Pathology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaUnited Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaXiang An Biomedicine Laboratory, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaXiang An Biomedicine Laboratory, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaXiang An Biomedicine Laboratory, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaXiang An Biomedicine Laboratory, Xiamen University, Xiamen, ChinaDepartment of Severe Hepatology, Shanghai Public Health Clinical Centre, Fudan University, Shanghai, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Life Sciences, Xiamen University, Xiamen, ChinaXiang An Biomedicine Laboratory, Xiamen University, Xiamen, ChinaResearch Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen, ChinaHepatitis E virus (HEV) is one of the most important public health issues around the world, and chronic HEV infection has been reported in immunosuppressed individuals. This study reported a male case, with very severe aplastic anemia (AA), who developed chronic hepatitis E after hematopoietic stem cell transplantation (HSCT). Abnormal alanine aminotransferase (ALT) appeared after HSCT and persisted for twenty-nine months. The case was seropositive for anti-HEV IgG and IgM after HSCT. Twenty-two months after HSCT, HEV RNA and antigen (Ag) testing were positive and persisted for five and seven months, respectively. Positive stains of HEV Ag were present in a liver biopsy sample. HEV Ag was present in bone marrow. The individual rapidly developed liver cirrhosis and was rescued by a regimen of oral ribavirin. These factors suggested there is a risk of HEV infection in HSCT recipients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.954697/fullhepatitis E viruschronic hepatitishematopoietic stem cells transplantationcirrhosisaplastic anemia |
| spellingShingle | Zihao Chen Junfeng Wei Li Jiang Dong Ying Dong Ying Weikun Tian Weikun Tian Mengyang Zhang Guiping Wen Siling Wang Chang Liu Yingbin Wang Yingbin Wang Ting Wu Ting Wu Zimin Tang Zimin Tang Zizheng Zheng Zizheng Zheng Li Yan Ningshao Xia Ningshao Xia Ningshao Xia Ningshao Xia Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient Frontiers in Immunology hepatitis E virus chronic hepatitis hematopoietic stem cells transplantation cirrhosis aplastic anemia |
| title | Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient |
| title_full | Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient |
| title_fullStr | Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient |
| title_full_unstemmed | Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient |
| title_short | Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient |
| title_sort | case report chronic hepatitis e in a hematopoietic stem cell transplant recipient the first report of hepatitis e virus genotype 4 causing chronic infection in a non solid organ recipient |
| topic | hepatitis E virus chronic hepatitis hematopoietic stem cells transplantation cirrhosis aplastic anemia |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.954697/full |
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