Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank
Abstract Background Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between cannabis use and the risk of urological cancers. Methods We identified 151,945 ind...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5132 |
| _version_ | 1797903127834263552 |
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| author | Jingyi Huang Da Huang Xiaohao Ruan Jinlun Huang Danfeng Xu Susan Heavey Jonathan Olivier Rong Na |
| author_facet | Jingyi Huang Da Huang Xiaohao Ruan Jinlun Huang Danfeng Xu Susan Heavey Jonathan Olivier Rong Na |
| author_sort | Jingyi Huang |
| collection | DOAJ |
| description | Abstract Background Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between cannabis use and the risk of urological cancers. Methods We identified 151,945 individuals with information on cannabis use in the UK Biobank from 2006 to 2010. Crude and age‐standardized incidence ratios of different urological cancers were evaluated in the entire cohort and subgroups. Cox regression was performed for survival analysis. Results Previous use of cannabis was a significant protective factor for renal cell carcinoma (HR = 0.61, 95%CI:0.40–0.93, p = 0.021) and prostate cancer (HR = 0.82, 95%CI:0.73–0.93, p = 0.002) in multivariable analysis. The association between previous cannabis use and both renal cell carcinoma and bladder cancer was only observed in females (HRRCC = 0.42, 95%CI:0.19–0.94, p = 0.034; HRBCa = 0.43, 95%CI:0.21–0.86, p = 0.018) but not in men. There was no significant association between cannabis use and testicular cancer incidence. Mendelian randomization demonstrated a potential causal effect of cannabis use on a lower incidence of renal cell carcinoma. Conclusions Previous use of cannabis was associated with a lower risk of bladder cancer, renal cell carcinoma, and prostate cancer. The inverse association between cannabis and both renal cell carcinoma and bladder cancer was only found in females but not in males. |
| first_indexed | 2024-04-10T09:28:04Z |
| format | Article |
| id | doaj.art-c2cbffe47a4945119645905a03bf60a1 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T09:28:04Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-c2cbffe47a4945119645905a03bf60a12023-02-19T18:54:08ZengWileyCancer Medicine2045-76342023-02-011233468347610.1002/cam4.5132Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobankJingyi Huang0Da Huang1Xiaohao Ruan2Jinlun Huang3Danfeng Xu4Susan Heavey5Jonathan Olivier6Rong Na7Department of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Urology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDivision of Surgery and Interventional Sciences University College London London UKDepartment of Urology, CHU Lille Claude Huriez Hospital, University of Lille Lille FranceDivision of Urology, Department of Surgery Queen Mary Hospital, The University of Hong Kong Hong KongAbstract Background Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between cannabis use and the risk of urological cancers. Methods We identified 151,945 individuals with information on cannabis use in the UK Biobank from 2006 to 2010. Crude and age‐standardized incidence ratios of different urological cancers were evaluated in the entire cohort and subgroups. Cox regression was performed for survival analysis. Results Previous use of cannabis was a significant protective factor for renal cell carcinoma (HR = 0.61, 95%CI:0.40–0.93, p = 0.021) and prostate cancer (HR = 0.82, 95%CI:0.73–0.93, p = 0.002) in multivariable analysis. The association between previous cannabis use and both renal cell carcinoma and bladder cancer was only observed in females (HRRCC = 0.42, 95%CI:0.19–0.94, p = 0.034; HRBCa = 0.43, 95%CI:0.21–0.86, p = 0.018) but not in men. There was no significant association between cannabis use and testicular cancer incidence. Mendelian randomization demonstrated a potential causal effect of cannabis use on a lower incidence of renal cell carcinoma. Conclusions Previous use of cannabis was associated with a lower risk of bladder cancer, renal cell carcinoma, and prostate cancer. The inverse association between cannabis and both renal cell carcinoma and bladder cancer was only found in females but not in males.https://doi.org/10.1002/cam4.5132bladder cancercannabisincidenceprostate cancerrenal cell carcinomatesticular cancer |
| spellingShingle | Jingyi Huang Da Huang Xiaohao Ruan Jinlun Huang Danfeng Xu Susan Heavey Jonathan Olivier Rong Na Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank Cancer Medicine bladder cancer cannabis incidence prostate cancer renal cell carcinoma testicular cancer |
| title | Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank |
| title_full | Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank |
| title_fullStr | Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank |
| title_full_unstemmed | Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank |
| title_short | Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank |
| title_sort | association between cannabis use with urological cancers a population based cohort study and a mendelian randomization study in the uk biobank |
| topic | bladder cancer cannabis incidence prostate cancer renal cell carcinoma testicular cancer |
| url | https://doi.org/10.1002/cam4.5132 |
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