Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals
IntroductionBeing able to independently determine vaccine induced antibody responses by minimal-invasive methods is of great interest to enable a flexible and effective vaccination strategy. This study aimed to evaluate (1) the accuracy, feasibility, usability and acceptability of capillary blood an...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.994770/full |
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| author | Caroline Schmetzer Caroline Schmetzer Ekaterina Vogt Laura Stellar Elie-Tino Godonou Elie-Tino Godonou Anna-Maria Liphardt Anna-Maria Liphardt Felix Muehlensiepen Felix Muehlensiepen Felix Muehlensiepen Nicolas Vuillerme Nicolas Vuillerme Nicolas Vuillerme Axel J. Hueber Axel J. Hueber Arnd Kleyer Arnd Kleyer Gerhard Krönke Gerhard Krönke Georg Schett Georg Schett David Simon David Simon Johannes Knitza Johannes Knitza Johannes Knitza |
| author_facet | Caroline Schmetzer Caroline Schmetzer Ekaterina Vogt Laura Stellar Elie-Tino Godonou Elie-Tino Godonou Anna-Maria Liphardt Anna-Maria Liphardt Felix Muehlensiepen Felix Muehlensiepen Felix Muehlensiepen Nicolas Vuillerme Nicolas Vuillerme Nicolas Vuillerme Axel J. Hueber Axel J. Hueber Arnd Kleyer Arnd Kleyer Gerhard Krönke Gerhard Krönke Georg Schett Georg Schett David Simon David Simon Johannes Knitza Johannes Knitza Johannes Knitza |
| author_sort | Caroline Schmetzer |
| collection | DOAJ |
| description | IntroductionBeing able to independently determine vaccine induced antibody responses by minimal-invasive methods is of great interest to enable a flexible and effective vaccination strategy. This study aimed to evaluate (1) the accuracy, feasibility, usability and acceptability of capillary blood and saliva self-sampling to determine SARS-CoV-2 antibody responses in patients with immune-mediated inflammatory diseases (IMIDs) and health professionals (HP).MethodsIMID patients and HP having received two doses of SARS-CoV-2 vaccines, self-collected capillary blood (Tasso+) and saliva samples. Capillary samples were considered interchangeable with venous blood if three criteria were met: Spearman's correlation coefficient (r) > 0.8, non-significant Wilcoxon signed-rank test (i.e., p > 0.05), and a small bias or 95% of tests within 10% difference through Bland-Altman. Participants completed a survey to investigate self-sampling usability (system usability scale; SUS) and acceptability (net promoter score; NPS). Study personnel monitored correct self-sampling completion and recorded protocol deviations.Results60 participants (30 IMID patients and 30 HP) were analyzed. We observed interchangeability for capillary samples with an accuracy of 98.3/100% for Anti-SARS-CoV-2 IgG/IgA antibodies, respectively. Fifty-eight capillary blood samples and all 60 saliva samples were successfully collected within the first attempt. Usability of both self-sampling procedures was rated as excellent, with significantly higher saliva ratings (p < 0.001). Capillary self-sampling was perceived as significantly (p < 0.001) less painful compared to traditional venous blood collection. Participants reported a NPS for capillary and saliva self-sampling of +68% and +63%, respectively. The majority of both groups (73%) preferred capillary self-sampling over professional venous blood collection.ConclusionOur results indicate that capillary self-sampling is accurate, feasible and preferred over conventional venous blood collection. Implementation could enable easy access, flexible vaccination monitoring, potentially leading to a better protection of vulnerable patient groups. Self-collection of saliva is feasible and safe however more work is needed to determine its application in clinical practice. |
| first_indexed | 2024-04-11T16:46:30Z |
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| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T16:46:30Z |
| publishDate | 2022-10-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-c2cc193625924180b31af9b1ee5eb99c2022-12-22T04:13:33ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.994770994770Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionalsCaroline Schmetzer0Caroline Schmetzer1Ekaterina Vogt2Laura Stellar3Elie-Tino Godonou4Elie-Tino Godonou5Anna-Maria Liphardt6Anna-Maria Liphardt7Felix Muehlensiepen8Felix Muehlensiepen9Felix Muehlensiepen10Nicolas Vuillerme11Nicolas Vuillerme12Nicolas Vuillerme13Axel J. Hueber14Axel J. Hueber15Arnd Kleyer16Arnd Kleyer17Gerhard Krönke18Gerhard Krönke19Georg Schett20Georg Schett21David Simon22David Simon23Johannes Knitza24Johannes Knitza25Johannes Knitza26Department of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyThermo Fisher Scientific, Freiburg, GermanyThermo Fisher Scientific, Freiburg, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyCentre for Health Services Research Brandenburg, Brandenburg Medical School, Neuruppin, GermanyFaculty of Health Sciences Brandenburg, Brandenburg Medical School, Neuruppin, GermanyUniversité Grenoble Alpes, AGEIS, Grenoble, FranceUniversité Grenoble Alpes, AGEIS, Grenoble, FranceInstitut Universitaire de France, Paris, FranceLabCom Telecom4Health, Orange Labs and Univ. Grenoble Alpes, CNRS, Inria, Grenoble INP-UGA, Grenoble, FranceDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDivision of Rheumatology, Klinikum Nürnberg, Paracelsus Medical University, Nürnberg, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDepartment of Internal Medicine 3 – Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, GermanyUniversité Grenoble Alpes, AGEIS, Grenoble, FranceIntroductionBeing able to independently determine vaccine induced antibody responses by minimal-invasive methods is of great interest to enable a flexible and effective vaccination strategy. This study aimed to evaluate (1) the accuracy, feasibility, usability and acceptability of capillary blood and saliva self-sampling to determine SARS-CoV-2 antibody responses in patients with immune-mediated inflammatory diseases (IMIDs) and health professionals (HP).MethodsIMID patients and HP having received two doses of SARS-CoV-2 vaccines, self-collected capillary blood (Tasso+) and saliva samples. Capillary samples were considered interchangeable with venous blood if three criteria were met: Spearman's correlation coefficient (r) > 0.8, non-significant Wilcoxon signed-rank test (i.e., p > 0.05), and a small bias or 95% of tests within 10% difference through Bland-Altman. Participants completed a survey to investigate self-sampling usability (system usability scale; SUS) and acceptability (net promoter score; NPS). Study personnel monitored correct self-sampling completion and recorded protocol deviations.Results60 participants (30 IMID patients and 30 HP) were analyzed. We observed interchangeability for capillary samples with an accuracy of 98.3/100% for Anti-SARS-CoV-2 IgG/IgA antibodies, respectively. Fifty-eight capillary blood samples and all 60 saliva samples were successfully collected within the first attempt. Usability of both self-sampling procedures was rated as excellent, with significantly higher saliva ratings (p < 0.001). Capillary self-sampling was perceived as significantly (p < 0.001) less painful compared to traditional venous blood collection. Participants reported a NPS for capillary and saliva self-sampling of +68% and +63%, respectively. The majority of both groups (73%) preferred capillary self-sampling over professional venous blood collection.ConclusionOur results indicate that capillary self-sampling is accurate, feasible and preferred over conventional venous blood collection. Implementation could enable easy access, flexible vaccination monitoring, potentially leading to a better protection of vulnerable patient groups. Self-collection of saliva is feasible and safe however more work is needed to determine its application in clinical practice.https://www.frontiersin.org/articles/10.3389/fpubh.2022.994770/fullself-collectioncapillary bloodremote caretelehealthself-samplingCOVID-19 |
| spellingShingle | Caroline Schmetzer Caroline Schmetzer Ekaterina Vogt Laura Stellar Elie-Tino Godonou Elie-Tino Godonou Anna-Maria Liphardt Anna-Maria Liphardt Felix Muehlensiepen Felix Muehlensiepen Felix Muehlensiepen Nicolas Vuillerme Nicolas Vuillerme Nicolas Vuillerme Axel J. Hueber Axel J. Hueber Arnd Kleyer Arnd Kleyer Gerhard Krönke Gerhard Krönke Georg Schett Georg Schett David Simon David Simon Johannes Knitza Johannes Knitza Johannes Knitza Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals Frontiers in Public Health self-collection capillary blood remote care telehealth self-sampling COVID-19 |
| title | Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals |
| title_full | Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals |
| title_fullStr | Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals |
| title_full_unstemmed | Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals |
| title_short | Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals |
| title_sort | self collection of capillary blood and saliva to determine covid 19 vaccine immunogenicity in patients with immune mediated inflammatory diseases and health professionals |
| topic | self-collection capillary blood remote care telehealth self-sampling COVID-19 |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.994770/full |
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