The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility
Nowadays, infertility is one of the most common problems in the world. Statistics show that about 20.2% of Iranian couples are infertile, which is higher than the global average (12-15 percent); and according to the reports, 70% of these disabilities had male factors. New approaches are available to...
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Isfahan University of Medical Sciences
2020-09-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/12860 |
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| author | Motahareh Sadat Mousavi Abdolhossein Shahverdi Mohsen Sharafi Pegah Rahimizadeh Ali Reza Alizadeh |
| author_facet | Motahareh Sadat Mousavi Abdolhossein Shahverdi Mohsen Sharafi Pegah Rahimizadeh Ali Reza Alizadeh |
| author_sort | Motahareh Sadat Mousavi |
| collection | DOAJ |
| description | Nowadays, infertility is one of the most common problems in the world. Statistics show that about 20.2% of Iranian couples are infertile, which is higher than the global average (12-15 percent); and according to the reports, 70% of these disabilities had male factors. New approaches are available to diagnose male infertility problems; one of them is the study of nuclear receptors. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor super family that have been implicated in energy homeostasis, and modulate lipid and glucose metabolism. Although several studies have been confirmed the pivotal roles of these receptors on fatty acid metabolism and female fertility, fewer information exist on PPARs roles in male fertility. Thus, in this review, we at first illustrated the role of PPARs in reproductive tissues. Then, specific studies on the effect of these receptors and their ligands in male reproductive tissues were described. Regarding the crucial role of sperm metabolism and producing sufficient energy for sperm motility in male fertility, the regulation of PPARs expression, particularly the PPARγ isotype on spermatogenesis and sperm movement parameters were investigated, in the following. It seems that the study of these receptors and their role in sperm metabolism, may afford novel research opportunities for the recognition of these receptors and their interactions with other nuclear receptors role in male infertility disorders imputable to metabolic diseases such as obesity and diabetes. |
| first_indexed | 2024-03-12T08:37:08Z |
| format | Article |
| id | doaj.art-c2cecc2517ae4220ac5c8622b45a50e5 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:37:08Z |
| publishDate | 2020-09-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-c2cecc2517ae4220ac5c8622b45a50e52023-09-02T17:10:46ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2020-09-013858350351110.22122/jims.v38i583.128603682The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male FertilityMotahareh Sadat Mousavi0Abdolhossein Shahverdi1Mohsen Sharafi2Pegah Rahimizadeh3Ali Reza Alizadeh4Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research (ACECR), Tehran, IranProfessor, Department of Embryology, Reproductive Biomedicine Research Center AND Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research (ACECR), Tehran, IranAssistant Professor, Department of Poultry Science, School of Agriculture, Tarbiat Modares University, Tehran, IranDepartment of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research (ACECR), Tehran, IranAssistant Professor, Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research (ACECR), Tehran, IranNowadays, infertility is one of the most common problems in the world. Statistics show that about 20.2% of Iranian couples are infertile, which is higher than the global average (12-15 percent); and according to the reports, 70% of these disabilities had male factors. New approaches are available to diagnose male infertility problems; one of them is the study of nuclear receptors. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor super family that have been implicated in energy homeostasis, and modulate lipid and glucose metabolism. Although several studies have been confirmed the pivotal roles of these receptors on fatty acid metabolism and female fertility, fewer information exist on PPARs roles in male fertility. Thus, in this review, we at first illustrated the role of PPARs in reproductive tissues. Then, specific studies on the effect of these receptors and their ligands in male reproductive tissues were described. Regarding the crucial role of sperm metabolism and producing sufficient energy for sperm motility in male fertility, the regulation of PPARs expression, particularly the PPARγ isotype on spermatogenesis and sperm movement parameters were investigated, in the following. It seems that the study of these receptors and their role in sperm metabolism, may afford novel research opportunities for the recognition of these receptors and their interactions with other nuclear receptors role in male infertility disorders imputable to metabolic diseases such as obesity and diabetes.http://jims.mui.ac.ir/index.php/jims/article/view/12860spermperoxisome proliferator-activated receptorsmetabolisminfertilitymalereproduction |
| spellingShingle | Motahareh Sadat Mousavi Abdolhossein Shahverdi Mohsen Sharafi Pegah Rahimizadeh Ali Reza Alizadeh The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility مجله دانشکده پزشکی اصفهان sperm peroxisome proliferator-activated receptors metabolism infertility male reproduction |
| title | The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility |
| title_full | The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility |
| title_fullStr | The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility |
| title_full_unstemmed | The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility |
| title_short | The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility |
| title_sort | effect of peroxisome proliferator activated receptors ppars in male fertility |
| topic | sperm peroxisome proliferator-activated receptors metabolism infertility male reproduction |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/12860 |
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