Cancer-related functions and subcellular localizations of septins
Since the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00126/full |
| _version_ | 1828320954745356288 |
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| author | Christian Poüs Christian Poüs Laurence Klipfel Laurence Klipfel Anita Baillet |
| author_facet | Christian Poüs Christian Poüs Laurence Klipfel Laurence Klipfel Anita Baillet |
| author_sort | Christian Poüs |
| collection | DOAJ |
| description | Since the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pathologies, including neurological disorders and cancer. In this minireview, we focus on the importance of the subunit composition and subcellular localization of septins relevant to tumor initiation, progression and metastasis. We especially underline the importance of septin polymer composition and of their association with the plasma membrane, actin or microtubules in cell functions involved in cancer and in resistance to cancer therapies. Through their scaffolding role, their function in membrane compartmentalization or through their protective function against protein degradation, septins also emerge as critical organizers of membrane-associated proteins and of signaling pathways implicated in cancer-associated angiogenesis, apoptosis, polarity, migration, proliferation and in metastasis. Also, the question as to which of the free monomers, hetero-oligomers or filaments is the functional form of mammalian septins is raised and the control over their spatial and temporal localization is discussed. The increasing amount of crosstalks identified between septins and cellular signaling mediators reinforces the exciting possibility that septins could be new targets in anti-cancer therapies or in therapeutic strategies to limit drug resistance. |
| first_indexed | 2024-04-13T18:19:07Z |
| format | Article |
| id | doaj.art-c2cefe9d059f4fb4b2201da7bfce7350 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T18:19:07Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c2cefe9d059f4fb4b2201da7bfce73502022-12-22T02:35:33ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2016-11-01410.3389/fcell.2016.00126228379Cancer-related functions and subcellular localizations of septinsChristian Poüs0Christian Poüs1Laurence Klipfel2Laurence Klipfel3Anita Baillet4Univ. Paris Sud, Université Paris-SaclayAPHP, Hôpital Antoine BéclèreUniv. Paris Sud, Université Paris-SaclayUniv. Pierre et Marie Curie Paris 06, Sorbonne Universités, INSERM UMR-S 968, CNRS UMR 7210Univ. Paris Sud, Université Paris-SaclaySince the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pathologies, including neurological disorders and cancer. In this minireview, we focus on the importance of the subunit composition and subcellular localization of septins relevant to tumor initiation, progression and metastasis. We especially underline the importance of septin polymer composition and of their association with the plasma membrane, actin or microtubules in cell functions involved in cancer and in resistance to cancer therapies. Through their scaffolding role, their function in membrane compartmentalization or through their protective function against protein degradation, septins also emerge as critical organizers of membrane-associated proteins and of signaling pathways implicated in cancer-associated angiogenesis, apoptosis, polarity, migration, proliferation and in metastasis. Also, the question as to which of the free monomers, hetero-oligomers or filaments is the functional form of mammalian septins is raised and the control over their spatial and temporal localization is discussed. The increasing amount of crosstalks identified between septins and cellular signaling mediators reinforces the exciting possibility that septins could be new targets in anti-cancer therapies or in therapeutic strategies to limit drug resistance.http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00126/fullActin CytoskeletonMicrotubulesCancerplasma membraneSeptin |
| spellingShingle | Christian Poüs Christian Poüs Laurence Klipfel Laurence Klipfel Anita Baillet Cancer-related functions and subcellular localizations of septins Frontiers in Cell and Developmental Biology Actin Cytoskeleton Microtubules Cancer plasma membrane Septin |
| title | Cancer-related functions and subcellular localizations of septins |
| title_full | Cancer-related functions and subcellular localizations of septins |
| title_fullStr | Cancer-related functions and subcellular localizations of septins |
| title_full_unstemmed | Cancer-related functions and subcellular localizations of septins |
| title_short | Cancer-related functions and subcellular localizations of septins |
| title_sort | cancer related functions and subcellular localizations of septins |
| topic | Actin Cytoskeleton Microtubules Cancer plasma membrane Septin |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00126/full |
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