Collateral sensitivity associated with antibiotic resistance plasmids
Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies desig...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/65130 |
| _version_ | 1811180563456851968 |
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| author | Cristina Herencias Jerónimo Rodríguez-Beltrán Ricardo León-Sampedro Aida Alonso-del Valle Jana Palkovičová Rafael Cantón Álvaro San Millán |
| author_facet | Cristina Herencias Jerónimo Rodríguez-Beltrán Ricardo León-Sampedro Aida Alonso-del Valle Jana Palkovičová Rafael Cantón Álvaro San Millán |
| author_sort | Cristina Herencias |
| collection | DOAJ |
| description | Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies designed against ABR mediated by chromosomal mutations. However, one of the main drivers of ABR in clinically relevant bacteria is the horizontal transfer of ABR genes mediated by plasmids. Here, we report the first analysis of CS associated with the acquisition of complete ABR plasmids, including the clinically important carbapenem-resistance conjugative plasmid pOXA-48. In addition, we describe the conservation of CS in clinical E. coli isolates and its application to selectively kill plasmid-carrying bacteria. Our results provide new insights that establish the basis for developing CS-informed treatment strategies to combat plasmid-mediated ABR. |
| first_indexed | 2024-04-11T09:05:25Z |
| format | Article |
| id | doaj.art-c2d0354829ac479db07608ff95e9568f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:25Z |
| publishDate | 2021-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c2d0354829ac479db07608ff95e9568f2022-12-22T04:32:39ZengeLife Sciences Publications LtdeLife2050-084X2021-01-011010.7554/eLife.65130Collateral sensitivity associated with antibiotic resistance plasmidsCristina Herencias0https://orcid.org/0000-0002-1384-3109Jerónimo Rodríguez-Beltrán1https://orcid.org/0000-0003-3014-1229Ricardo León-Sampedro2https://orcid.org/0000-0001-5317-8310Aida Alonso-del Valle3https://orcid.org/0000-0002-5154-5778Jana Palkovičová4https://orcid.org/0000-0003-4836-5239Rafael Cantón5https://orcid.org/0000-0003-1675-3173Álvaro San Millán6https://orcid.org/0000-0001-8544-0387Servicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, SpainServicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; Centro de Investigación Biológica en Red Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, SpainServicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; Centro de Investigación Biológica en Red Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, SpainServicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, SpainDepartment of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech RepublicServicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; Red Española de Investigación en Patología Infecciosa. Instituto de Salud Carlos III, Madrid, SpainServicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; Centro de Investigación Biológica en Red Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain; Centro Nacional de Biotecnología-CSIC, Madrid, SpainCollateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies designed against ABR mediated by chromosomal mutations. However, one of the main drivers of ABR in clinically relevant bacteria is the horizontal transfer of ABR genes mediated by plasmids. Here, we report the first analysis of CS associated with the acquisition of complete ABR plasmids, including the clinically important carbapenem-resistance conjugative plasmid pOXA-48. In addition, we describe the conservation of CS in clinical E. coli isolates and its application to selectively kill plasmid-carrying bacteria. Our results provide new insights that establish the basis for developing CS-informed treatment strategies to combat plasmid-mediated ABR.https://elifesciences.org/articles/65130antibioticscollateral sensitivityplasmid |
| spellingShingle | Cristina Herencias Jerónimo Rodríguez-Beltrán Ricardo León-Sampedro Aida Alonso-del Valle Jana Palkovičová Rafael Cantón Álvaro San Millán Collateral sensitivity associated with antibiotic resistance plasmids eLife antibiotics collateral sensitivity plasmid |
| title | Collateral sensitivity associated with antibiotic resistance plasmids |
| title_full | Collateral sensitivity associated with antibiotic resistance plasmids |
| title_fullStr | Collateral sensitivity associated with antibiotic resistance plasmids |
| title_full_unstemmed | Collateral sensitivity associated with antibiotic resistance plasmids |
| title_short | Collateral sensitivity associated with antibiotic resistance plasmids |
| title_sort | collateral sensitivity associated with antibiotic resistance plasmids |
| topic | antibiotics collateral sensitivity plasmid |
| url | https://elifesciences.org/articles/65130 |
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