Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Summary: Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expressi...

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Bibliographic Details
Main Authors: Jérôme Gilleron, Gwennaëlle Bouget, Stoyan Ivanov, Cindy Meziat, Franck Ceppo, Bastien Vergoni, Mansour Djedaini, Antoine Soprani, Karine Dumas, Arnaud Jacquel, Laurent Yvan-Charvet, Nicolas Venteclef, Jean-François Tanti, Mireille Cormont
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318746

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http://www.sciencedirect.com/science/article/pii/S2211124718318746

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