Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations
Introduction: Interpretation of “lung age” data relies upon comparison of the chronological lung age (CLA) with the estimated lung age (ELA) predicted from published reference equations [7–10]. Aim: To test the applicability of the published reference equations in healthy non-smoker Tunisian aged 19...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-10-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763813002100 |
| _version_ | 1828261357379649536 |
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| author | H. Ben Saad A. Elhraiech K. Hadj Mabrouk S. Ben Mdalla M. Essghaier C. Maatoug A. Abdelghani H. Bouslah A. Charrada S. Rouatbi |
| author_facet | H. Ben Saad A. Elhraiech K. Hadj Mabrouk S. Ben Mdalla M. Essghaier C. Maatoug A. Abdelghani H. Bouslah A. Charrada S. Rouatbi |
| author_sort | H. Ben Saad |
| collection | DOAJ |
| description | Introduction: Interpretation of “lung age” data relies upon comparison of the chronological lung age (CLA) with the estimated lung age (ELA) predicted from published reference equations [7–10].
Aim: To test the applicability of the published reference equations in healthy non-smoker Tunisian aged 19–90 years.
Population and methods: Published reference equations were applied to the spirometry results of 540 adults (364 women). Two methods of comparison were applied: (i) Determination, according each equation, of the percentages of subjects having a deltaLungAge (=ELA–CLA) > Upper-Limit-of-Normal (ULN). (ii) Bland and Altman comparison, for the same age range as in the corresponding study, between CLA and ELA.
Results: The mean ± SD (95% confidence interval) of the total sample CLA and height were 48.8 ± 13.1 (47.7–49.9) years and 164 ± 10 (163–165) cm. (i) The percentages of healthy subjects with a deltaLungAge > ULN varied from 1% (Newbury) to 64% (Hansen) in men, and from 20% (Yamaguchi) to 51% (Hansen, Morris and Temple) for women. (ii) Mean ± SD ELA was significantly underestimated by 17 ± 19 years (Hansen), by 12 ± 23 years (Morris and Temple) and was significantly overestimated by 4 ± 19 years (Newbury). Mean ± SD ELA from Yamaguchi et al. [10] was not statistically different from the CLA (1 ± 14 years).
Conclusion: The published reference equations did not reliably predict CLA data in the Tunisian population. Awaiting the establishment of reliable equation proper to North African population, we recommend the use of the Yamaguchi et al.’s [10] reference equations. |
| first_indexed | 2024-04-13T03:38:25Z |
| format | Article |
| id | doaj.art-c2d2479c478844a09d8c08f4ec723e00 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-04-13T03:38:25Z |
| publishDate | 2013-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-c2d2479c478844a09d8c08f4ec723e002022-12-22T03:04:14ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382013-10-0162478980410.1016/j.ejcdt.2013.09.018Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populationsH. Ben Saad0A. Elhraiech1K. Hadj Mabrouk2S. Ben Mdalla3M. Essghaier4C. Maatoug5A. Abdelghani6H. Bouslah7A. Charrada8S. Rouatbi9Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, TunisiaFunctional Exploration Laboratory, Occupational Medicine Group of Sousse, TunisiaFunctional Exploration Laboratory, Occupational Medicine Group of Sousse, TunisiaDepartment of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, TunisiaDepartment of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, TunisiaFunctional Exploration Laboratory, Occupational Medicine Group of Sousse, TunisiaResearch Unit: prevention secondaire après infarctus du mypcarde, N°: 04/UR/08-18, Faculty of Medicine of Sousse, Sousse, TunisiaFunctional Exploration Laboratory, Occupational Medicine Group of Sousse, TunisiaFunctional Exploration Laboratory, Occupational Medicine Group of Sousse, TunisiaDepartment of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, TunisiaIntroduction: Interpretation of “lung age” data relies upon comparison of the chronological lung age (CLA) with the estimated lung age (ELA) predicted from published reference equations [7–10]. Aim: To test the applicability of the published reference equations in healthy non-smoker Tunisian aged 19–90 years. Population and methods: Published reference equations were applied to the spirometry results of 540 adults (364 women). Two methods of comparison were applied: (i) Determination, according each equation, of the percentages of subjects having a deltaLungAge (=ELA–CLA) > Upper-Limit-of-Normal (ULN). (ii) Bland and Altman comparison, for the same age range as in the corresponding study, between CLA and ELA. Results: The mean ± SD (95% confidence interval) of the total sample CLA and height were 48.8 ± 13.1 (47.7–49.9) years and 164 ± 10 (163–165) cm. (i) The percentages of healthy subjects with a deltaLungAge > ULN varied from 1% (Newbury) to 64% (Hansen) in men, and from 20% (Yamaguchi) to 51% (Hansen, Morris and Temple) for women. (ii) Mean ± SD ELA was significantly underestimated by 17 ± 19 years (Hansen), by 12 ± 23 years (Morris and Temple) and was significantly overestimated by 4 ± 19 years (Newbury). Mean ± SD ELA from Yamaguchi et al. [10] was not statistically different from the CLA (1 ± 14 years). Conclusion: The published reference equations did not reliably predict CLA data in the Tunisian population. Awaiting the establishment of reliable equation proper to North African population, we recommend the use of the Yamaguchi et al.’s [10] reference equations.http://www.sciencedirect.com/science/article/pii/S0422763813002100Lung ageSmoking cessationSpirometryNorth AfricaReference equationLimits of normal |
| spellingShingle | H. Ben Saad A. Elhraiech K. Hadj Mabrouk S. Ben Mdalla M. Essghaier C. Maatoug A. Abdelghani H. Bouslah A. Charrada S. Rouatbi Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations Egyptian Journal of Chest Disease and Tuberculosis Lung age Smoking cessation Spirometry North Africa Reference equation Limits of normal |
| title | Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations |
| title_full | Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations |
| title_fullStr | Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations |
| title_full_unstemmed | Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations |
| title_short | Estimated lung age in healthy North African adults cannot be predicted using reference equations derived from other populations |
| title_sort | estimated lung age in healthy north african adults cannot be predicted using reference equations derived from other populations |
| topic | Lung age Smoking cessation Spirometry North Africa Reference equation Limits of normal |
| url | http://www.sciencedirect.com/science/article/pii/S0422763813002100 |
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